Incentives for new antibiotics: the Options Market for Antibiotics (OMA) model.
Incentives for new antibiotics: the Options Market for Antibiotics (OMA) model.
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DOI：
10.1186/1744-8603-9-58
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发表时间：
2013-11-07
影响因子：
10.8
通讯作者：
Mossialos E
中科院分区：
文献类型：
--
作者：
Brogan DM;Mossialos E
由于生物、经济和政治压力的共同作用，抗菌素耐药性是一个日益严重的威胁。对新抗菌剂研发的投资受到这些压力的影响，导致抗生素耐药性危机的出现。事实证明，目前刺激抗生素开发的政策不足以克服市场失灵。因此，需要利用市场力量的创新想法来刺激新的投资努力。采用前面描述的先进的市场承诺和改进的看涨期权疫苗模型的好处，我们在这里描述了一种新的激励机制，抗生素的期权市场。该模型将金融看涨期权的好处应用于新抗生素的投资和购买。这一新模式的目标是为早期投资和风险分担提供一个有效的机制，同时保持可信的购买承诺，并激励公司最终将新抗生素推向市场。我们认为，抗生素期权市场（OMA）可能有助于克服与新抗生素开发相关的一些传统市场失灵。必须开展更多的工作，以开发更可靠的数学模型，为实际实施铺平道路。
Antimicrobial resistance is a growing threat resulting from the convergence of biological, economic and political pressures. Investment in research and development of new antimicrobials has suffered secondary to these pressures, leading to an emerging crisis in antibiotic resistance. Current policies to stimulate antibiotic development have proven inadequate to overcome market failures. Therefore innovative ideas utilizing market forces are necessary to stimulate new investment efforts. Employing the benefits of both the previously described Advanced Market Commitment and a refined Call Options for Vaccines model, we describe herein a novel incentive mechanism, the Options Market for Antibiotics. This model applies the benefits of a financial call option to the investment in and purchase of new antibiotics. The goal of this new model is to provide an effective mechanism for early investment and risk sharing while maintaining a credible purchase commitment and incentives for companies to ultimately bring new antibiotics to market. We believe that the Options Market for Antibiotics (OMA) may help to overcome some of the traditional market failures associated with the development of new antibiotics. Additional work must be done to develop a more robust mathematical model to pave the way for practical implementation.
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影响因子：
--
作者：
DiMasi, JA;Grabowski, HG;Vernon, J
通讯作者：
Vernon, J
影响因子：
9.7
作者：
Adams, CP;Brantner, VV
通讯作者：
Brantner, VV
影响因子：
120.1
作者：
Brogan, David;Mossialos, Elias
通讯作者：
Mossialos, Elias
DOI：
10.1136/bmj.c2115
发表时间：
2010-05-18
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Morel, Chantal M;Mossialos, Elias
通讯作者：
Mossialos, Elias
影响因子：
3.3
作者：
Mrazek, MF;Mossialos, E
通讯作者：
Mossialos, E