Low expression of p27Kip1, a cyclin-dependent kinase inhibitor, is a marker of poor prognosis in synovial sarcoma
Low expression of p27Kip1, a cyclin-dependent kinase inhibitor, is a marker of poor prognosis in synovial sarcoma
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DOI：
10.1002/1097-0142(20010301)91:5
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发表时间：
2001-03-01
期刊：
影响因子：
6.2
通讯作者：
Sasaki, K
中科院分区：
文献类型：
--
作者：
Kawauchi, S;Goto, Y;Sasaki, K
背景：p27（kip 1）是一种主要的细胞周期蛋白依赖性激酶抑制剂，参与细胞周期的G1-S转换，其低表达与肿瘤的侵袭性生长有关。它已被证明，积极的细胞增殖暗示与滑膜肉瘤患者预后不良。方法采用免疫组化方法检测55例原发性滑膜肉瘤中p27（kip 1）的表达，并分析其与滑膜肉瘤细胞增殖指标的关系，测定有丝分裂指数（MI）、Ki-67标记指数（Ki-67 LI）以及与不良预后相关的临床病理参数。结果：滑膜肉瘤中p27（kip 1）标记指数（p27（kip 1）LI）与MI（r =-0.44，P = 0.0007）和Ki-67 LI（r =-0.63，P < 0.0001）呈负相关; p27（kip 1）LI与肿瘤坏死（P = 0.019）和美国癌症联合委员会（AJCC）分期（P = 0.021）密切相关。生存分析显示p27（kip 1）LI是滑膜肉瘤患者总生存的独立预后因素（P = 0.0031）。结论：p27（kip 1）低表达可作为滑膜肉瘤预后不良的一个标志。(C)2001年美国癌症协会。
BACKGROUND, Low expression of p27(kip1), a dominant cyclin-dependent kinase inhibitor involved in G1-S transition of the cell cycle, recently has been reported to be associated with aggressive tumor growth. It has been shown that active cell proliferation alludes to poor prognosis in patients with synovial sarcoma. However, to the authors' knowledge, little is known about the clinicopathologic significance of p27(kip1) in synovial sarcoma.METHODS, p27(kip1) expression was examined immunohistochemically in 55 cases of primary synovial sarcoma, and the relations between p27(kip1) expression and several eel proliferation markers, i.e., mitotic index (MI), Ki-67 labeling index (Ki-67 LI), and clinicopathologic parameters related to poor prognosis, were determined. Univariate and multivariate survival analyses were performed to evaluate the prognostic significance of p27(kip1) expression in synovial sarcomas.RESULTS, p27(kip1) labeling index (p27(kip1) LI) correlated inversely with MI (r = - 0.44, P = 0.0007) and Ki-67 LI (r = -0.63, P < 0.0001). Of the clinicopathologic parameters examined, tumor necrosis (P = 0.019) and American Joint Committee on Cancer (AJCC) stage (P = 0.021) correlated significantly with p27(kip1) LI. Survival analysis showed that p27(kip1) LI was an independent prognostic factor for overall survival in patients with synovial sarcoma (P = 0.0031).CONCLUSIONS, The study results suggested that low expression of p27(kip1) may be useful as a marker of poor-prognosis synovial sarcoma. (C) 2001 American Cancer Society.