Epithelial mesenchymal transition: a new insight into the detection of circulating tumor cells.
Epithelial mesenchymal transition: a new insight into the detection of circulating tumor cells.
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DOI：
10.5402/2012/382010
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Rigaud M
中科院分区：
文献类型：
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作者：
Barrière G;Tartary M;Rigaud M
许多研究小组报道了外周血中循环肿瘤细胞（CTC）与转移性癌症患者预后不良的关系。这些结果基于CTC计数，未考虑细胞的分子特征。为了将CTC确立为可靠和准确的生物学标记物，新技术必须专注于CTC亚群：由上皮间质转化（EMT）产生的去分化循环肿瘤细胞（ddCTC）。为了选择和检测它们，已经提出了不同的方法，但没有一个仍然达到目标。技术进步和转化研究有望将CTC确立为真实的标志物。因此，针对每位患者的CTC评估分析将导致个性化随访和治疗。
Many research groups reported on the relation between circulating tumor cells (CTCs) in peripheral blood and worse prognosis for metastatic cancer patients. These results are based on CTCs counting and did not take into account molecular characteristics of cells. To establish CTCs as a reliable and accurate biological marker, new technologies must be focused on CTC subpopulations: dedifferentiated circulating tumor cells (ddCTCs) arising from epithelial mesenchymal transition (EMT). To select and detect them, different methods have been proposed but none has still reached the goal. Technical progress and translational research are expected to establish CTCs as a real marker. Thus CTC evaluation profiling for each patient will lead to personalize followup and therapy.