EFFECTS OF PHENCYCLIDINE ON UPTAKE OF CATECHOLAMINE-H-3 BY RAT STRIATAL AND HYPOTHALAMIC SYNAPTOSOMES
EFFECTS OF PHENCYCLIDINE ON UPTAKE OF CATECHOLAMINE-H-3 BY RAT STRIATAL AND HYPOTHALAMIC SYNAPTOSOMES
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DOI：
10.1016/0024-3205(76)90145-4
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发表时间：
1976-01-01
期刊：
影响因子：
6.1
通讯作者：
HEATH, RG
中科院分区：
文献类型：
--
作者：
GAREY, RE;HEATH, RG
拟精神病药苯环己哌啶（PCP）对大鼠纹状体和下丘脑富含突触体匀浆摄取~ 3 H-儿茶酚胺的影响试验表明，PCP对纹状体区~ 3 H-多巴胺摄取和下丘脑~ 3 H-去甲肾上腺素摄取均具有竞争性抑制作用。这些研究结果的含义进行了讨论，在药物引起的不平衡的儿茶酚胺能-胆碱能系统在这些地区的大脑活动与情感表达。
The tests of the effects of the psychotomimetic agent, phencyclidine, 1-(1-phenylcyclohexl) piperidine (PCP), on the uptake of 3H-catecholamines by synaptosome-rich homogenates of rat striatum and hypothalamus, PCP was a potent, competitive inhibitor of both 3H dopamine uptake in the striatal region and 3H-norepinephrine uptake in the hypothalamus. The implication of these findings are discussed in terms of a drug-induced imbalance of the catecholaminergic-cholinergic systems in those regions of the brain where activity was correlated with emotional expression.