The clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the differential diagnosis, staging, and response evaluation after concurrent chemoradiotherapy for pancreatic cancer
The clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the differential diagnosis, staging, and response evaluation after concurrent chemoradiotherapy for pancreatic cancer
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DOI：
10.1097/01.mcg.0000225672.68852.05
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发表时间：
2006-11-01
影响因子：
2.9
通讯作者：
Song, Si Young
中科院分区：
文献类型：
--
作者：
Bang, Seungmin;Chung, Hye Won;Song, Si Young
目标：本研究的目的是确定临床使用18-氟脱氧葡萄糖正电子发射断层扫描（18）FDG-PET）在疑似胰腺癌患者的鉴别诊断，并在确定肿瘤反应后同步放化疗胰腺cancer.Background：尽管胰腺癌的诊断工具的进步，这是很难区分胰腺癌肿块形成胰腺炎。即使与目前的成像方式，它也很难评估肿瘤的反应治疗intervention.Study：一百零二例疑似胰腺癌患者被选为这项研究。动态计算机断层扫描（CT）和（18）FDG-PET依次用于诊断胰腺癌。在诊断确认后，比较它们的诊断产率。我们还评估了15例接受放化疗的患者的治疗反应与动态CT扫描和（18）FDG-PET，并比较其结果。（18）FDG-PET诊断符合率高于CT（95。1%对76.5%）。（18）FDG-PET对肝转移灶的检出率也优于CT，且具有上级优势。（18）15例放化疗后患者中5例FDG-PET检测到治疗反应。而CT不能检测到任何治疗反应。结果：（18）FDG-PET对胰腺癌的诊断有重要价值。（18）FDG-PET还可用作确定胰腺癌的治疗方式和评估肿瘤对放化疗的反应的辅助手段。
Goals: The aims of this study were to determine the clinical use of 18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) in the differential diagnosis of patients with suspected pancreatic cancer and in the determination of tumor response after concurrent chemo radio therapy for pancreatic cancer.Background: Despite advances in diagnostic tools for pancreatic cancer, it is difficult to differentiate pancreatic cancer from mass-forming pancreatitis. Even with current imaging modalities, it is also difficult to assess tumor response to therapeutic intervention.Study: One hundred two patients with suspected pancreatic cancer were selected for this study. Dynamic computerized tomography (CT) scan and (18)FDG-PET were used sequentially to diagnose pancreatic cancer. After diagnostic confirmation their diagnostic yields were compared. We also evaluated the treatment response in 15 patients who underwent chemoradiation therapy with dynamic CT scan and (18)FDG-PET and compared their results.Results: In 93 out of 102 patients, pancreatic cancer was confirmed. (18)FDG-PET showed higher diagnostic accuracy than CT scan (95. 1 % vs. 76.5%). (18)FDG-PET was also superior to CT in the detection of liver metastasis. (18)FDG-PET detected treatment response in 5 out of 15 cases after chemoradiation therapy. whereas CT could not detect any treatment response. Comparing responder and nonresponder, (18)FDG-PET was able to predict significantly different prognosis (399 vs. 233 d, P < 0.05).Conclusions: (18)FDG-PET is a very useful tool in diagnosing pancreatic cancer. (18)FDG-PET may be also used as an adjunct for determining the treatment modality of pancreatic cancer and evaluating tumor response to chemoradiation therapy.