Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis
Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis
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DOI：
10.1177/1352458513515082
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发表时间：
2014-07-01
影响因子：
5.8
通讯作者：
Bozzali, M.
中科院分区：
文献类型：
--
作者：
Basile, B.;Castelli, M.;Bozzali, M.
背景资料：在多发性硬化症（MS）中，局灶性病变的位置并不总是与临床症状相关，这表明断开连接是一种主要的病理生理机制。静息态（RS）功能磁共振成像（fMRI）被认为能反映特定神经元网络内的功能连接（FC）。目的：应用RS功能磁共振成像（RS fMRI）研究MS残疾的两个关键网络，即感觉-运动网络（SMN）和默认模式网络（DMN）内FC的变化。34名复发缓解型（RR）、14名继发性进展型（SP）MS患者和25名健康对照者接受了3 T MRI，包括常规图像、TI加权体积和RS-fMRI序列。采用独立成分分析（伊卡）提取每个参与者的相关RS网络的地图。进行组分析，以评估FC内的SMN和DMN在两个MS phenotypes.Results的变化：增加FC被发现在两个网络的MS患者。有趣的是，在任何一个方向的具体变化之间也观察到RR和SP MS groups.Conclusions：FC的变化似乎平行患者的临床状态和能力的补偿临床/认知障碍的严重程度。
Background: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks.Objective: RS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions.Methods: Thirty-four relapsing remitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, TI-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes.Results: Increased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups.Conclusions: FC changes seem to parallel patients' clinical state and capability of compensating for the severity of clinical/cognitive disabilities.