Staphylococcus aureus endocarditis -: A consequence of medical progress
Staphylococcus aureus endocarditis -: A consequence of medical progress
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DOI：
10.1001/jama.293.24.3012
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发表时间：
2005-06-22
影响因子：
120.7
通讯作者：
Bayer, AS
中科院分区：
文献类型：
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作者：
Fowler, VG;Miro, JM;Bayer, AS
背景 由金黄色葡萄球菌引起的感染性心内膜炎 (IE) 的全球意义尚不清楚。 目的 记录医疗相关金黄色葡萄球菌 IE 和耐甲氧西林金黄色葡萄球菌 (MRSA) IE 的国际出现情况，并评估金黄色葡萄球菌 IE 患者的区域差异。 设计、设置和参与者 在 16 个国家的 39 个医疗中心进行前瞻性观察队列研究。参与者是 1779 名根据杜克标准定义的确诊 IE 患者，他们于 2000 年 6 月至 2003 年 12 月期间参加了心内膜炎国际合作协作组前瞻性队列研究。主要结果指标为院内死亡率。结果 金黄色葡萄球菌是心内膜炎国际协作组前瞻性队列研究中 1779 例确诊 IE 病例中最常见的病原体（558患者，31.4%）。医疗保健相关感染是金黄色葡萄球菌 IE 最常见的形式（218 名患者，39.1%），占病例的 25.9%（澳大利亚/新西兰）至 54.2%（巴西）。大多数与医疗相关的金黄色葡萄球菌 I E 患者（131 名患者，60.1%）是在医院外感染的。 MRSA IE 在美国 (37.2%) 和巴西 (37.5%) 比欧洲/中东 (23.7%) 和澳大利亚/新西兰 (15.5%) 更常见
Context The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown.Objectives To document the international emergence of health care-associated S aureus IE and methicillin-resistant S aureus (MRSA) IE and to evaluate regional variation in patients with S aureus IE.Design, Setting, and Participants Prospective observational cohort study set in 39 medical centers in 16 countries. Participants were a population of 1779 patients with definite IE as defined by Duke criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to December 2003.Main Outcome Measure In-hospital mortality.Results S aureus was the most common pathogen among the 1779 cases of definite IE in the International Collaboration on Endocarditis Prospective-Cohort Study (558 patients, 31.4%). Health care-associated infection was the most common form of S aureus IE (218 patients, 39.1%), accounting for 25.9% (Australia/New Zealand) to 54.2% (Brazil) of cases. Most patients with health care-associated S aureus I E (131 patients, 60.1%) acquired the infection outside of the hospital. MRSA IE was more common in the United States (37.2%) and Brazil (37.5%) than in Europe/Middle East (23.7%) and Australia/ New Zealand (15.5%, P