New arguments for a vasculitic nature of polymyalgia rheumatica using positron emission tomography
New arguments for a vasculitic nature of polymyalgia rheumatica using positron emission tomography
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DOI：
10.1093/rheumatology/38.5.444
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发表时间：
1999-05-01
期刊：
影响因子：
5.5
通讯作者：
Mortelmans, L
中科院分区：
文献类型：
--
作者：
Blockmans, D;Maes, A;Mortelmans, L
Objective.目的探讨氟代脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）对巨细胞动脉炎和风湿性多肌痛的诊断价值。一个连续的病例系列包括5例风湿性多肌痛患者，6例颞动脉炎患者和23例年龄匹配的乙醚炎性疾病患者进行了评估与FDG-PET。在开始类固醇治疗前进行研究。6例巨细胞动脉炎和5例多肌痛患者中有4例胸部血管FDG摄取增加，而对照组中只有1例（P < 0.001）。巨细胞动脉炎或多肌痛患者中8/11例大腿血管FDG摄取增加，而对照组中8/23例大腿血管FDG摄取增加（P < 0.05）; 6/11例下肢血管FDG摄取增加，而对照组中6/23例下肢血管FDG摄取增加（P =无显著性）。FDG-PET扫描是第一个可以提示大血管炎的非侵入性技术，并且可以显示其在全身的扩展。它强烈表明风湿性多肌痛是一种血管炎。
Objective. To study the possible contribution of fluorodeoxyglucose (FDG)-positron emission tomography (PET) in the diagnosis of giant cell arteritis and polymyalgia rheumatica.Methods. A consecutive case series consisting of five patients with polymyalgia rheumatica, six patients with temporal arteritis and 23 age-matched patients with ether inflammatory conditions were evaluated with FDG-PET. Studies were performed before therapy with steroids was started.Results. A total of 4/6 patients with giant cell arteritis and 4/5 patients with polymyalgia had increased FDG uptake in their thoracic vessels, compared to 1/23 controls (P < 0.001). Increased vascular FDG uptake in the upper legs was seen in 8/11 patients with giant cell arteritis or polymyalgia compared to 8/23 control patients (P < 0.05), and in the lower legs in 6/11 patients compared to 6/23 controls (P = not significant).Conclusions. FDG-PET scan is the first non-invasive technique which may indicate large-vessel vasculitis and which ran show its extension throughout the body. It strongly suggests that polymyalgia rheumatica is a form of vasculitis.