Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries.
Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries.
复制标题
DOI：
10.1186/s12950-016-0144-1
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tonnessen TI
中科院分区：
文献类型：
--
作者：
Yang R;Zhu S;Tonnessen TI
丙酮酸乙酯（EP）是丙酮酸的简单衍生物，丙酮酸是一种重要的内源性代谢产物，可清除活性氧（ROS）。在多种动物模型中，EP治疗能够改善全身炎症和多器官功能障碍，例如急性胰腺炎、酒精性肝损伤、急性呼吸窘迫综合征（ARDS）、急性病毒性心肌炎、急性肾损伤和脓毒症。最近的研究表明，长期使用EP治疗可以改善实验性溃疡性结肠炎并减缓多发性肿瘤的生长。研究表明，EP具有抑制多种早期炎性细胞因子和晚期炎性细胞因子HMGB1释放的药理抗炎作用，其抗肿瘤活性可能与其抗炎作用有关。EP已在人类志愿者和美国接受心脏手术的患者的临床试验中进行了测试，并显示在临床相关剂量下是安全的，尽管EP未能改善心脏手术的结果，但EP仍然是治疗多炎性器官损伤患者的有前途的药物，其他临床试验正在进行中。本文综述了EP如何改善多器官损伤，并总结了最近发表的EP研究。抗炎药EP的作用靶点
Ethyl pyruvate (EP) is a simple derivative of pyruvic acid, which is an important endogenous metabolite that can scavenge reactive oxygen species (ROS). Treatment with EP is able to ameliorate systemic inflammation and multiple organ dysfunctions in multiple animal models, such as acute pancreatitis, alcoholic liver injury, acute respiratory distress syndrome (ARDS), acute viral myocarditis, acute kidney injury and sepsis. Recent studies have demonstrated that prolonged treatment with EP can ameliorate experimental ulcerative colitis and slow multiple tumor growth. It has become evident that EP has pharmacological anti-inflammatory effect to inhibit multiple early inflammatory cytokines and the late inflammatory cytokine HMGB1 release, and the anti-tumor activity is likely associated with its anti-inflammatory effect. EP has been tested in human volunteers and in a clinical trial of patients undergoing cardiac surgery in USA and shown to be safe at clinical relevant doses, even though EP fails to improve outcome of the heart surgery, EP is still a promising agent to treat patients with multiple inflammatory organ injuries and the other clinical trials are on the way. This review focuses on how EP is able to ameliorate multiple organ injuries and summarize recently published EP investigations. The targets of the anti-inflammatory agent EP
登录
查看更多内容
影响因子：
5.7
作者：
Antoine, Daniel James;Williams, Dominic P.;Park, B. Kevin
通讯作者：
Park, B. Kevin
影响因子：
6.1
作者：
Chen Hong;Li Fei;Sun Jia-bang
通讯作者：
Sun Jia-bang
影响因子：
2.6
作者：
Andersson, Bodil;Ansari, Daniel;Andersson, Roland
通讯作者：
Andersson, Roland
影响因子：
6.7
作者：
El Gazzar, M.
通讯作者：
El Gazzar, M.
影响因子：
2.8
作者：
Baunacke, Martin;Horn, Lars-Christian;Birkenmeier, Gerd
通讯作者：
Birkenmeier, Gerd