Is the incidence of registrable age-related macular degeneration increasing?
Is the incidence of registrable age-related macular degeneration increasing?
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DOI：
10.1136/bjo.80.1.9
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发表时间：
1996-01-01
影响因子：
4.1
通讯作者：
Wormald, R
中科院分区：
文献类型：
--
作者：
Evans, J;Wormald, R
年龄相关性黄斑变性（ARMD）在英国是一个日益严重的公共卫生问题，目前其病因尚不清楚。本研究的目的是测试的假设，年龄特定的致盲ARMD的发病率在过去的50年中，在英国增加，使用的数据的原因，视力丧失的人登记为盲人，发表自1950年以来，每10年一次。方法-数据是从1950年，1960年，1970年和1980年的出版物中提取。1990年标准年的数据由人口普查和调查处的数据库提供。将ARMD的新登记人数与白内障、青光眼和视神经萎缩的登记人数进行比较。间接标准化用于控制人口年龄结构随时间的变化。结果-在控制人口年龄结构的变化后，所有原因的登记率，白内障，青光眼，和视神经萎缩减少，而归因于ARMD的登记增加了30- 40%。这些发现与英国ARMD发病率正在增加的假设是一致的。然而，在这些数据中很难排除潜在的偏倚来源，特别是在原因分类和编码方面;需要更可靠的基于人群的英国ARMD数据。
Aims/Background-Age-related macular degeneration (ARMD) is a growing public health problem in Britain; currently its aetiology is unclear. The aim of this study was to test the hypothesis that the age specific incidence of blinding ARMD has increased in Britain in the past 50 years, using data on cause of visual loss in people registered as blind, published every 10 years since 1950.Methods - Data were abstracted from published sources for the years 1950, 1960, 1970, and 1980. Data for the standard year, 1990, were provided in a database from the Office of Population Censuses and Surveys. The numbers of new registrations attributed to ARMD per head of population were compared with registrations for cataract, glaucoma, and optic atrophy. Indirect standardisation was used to control for changes in the age structure of the population over time.Results - After controlling for changes in the age structure of the population, registration rates for all causes, cataract, glaucoma, and optic atrophy have decreased while registrations attributed to ARMD have increased in the order of 30-40%.Conclusions - These findings are compatible with the hypothesis that the incidence of ARMD is increasing in Britain. It is difficult to exclude potential sources of bias in these data, however, particularly with respect to classification and coding of cause; more reliable population based data on ARMD in Britain are needed.