Circular RNAs and Neuronal Development
Circular RNAs and Neuronal Development
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DOI：
10.1007/978-981-13-1426-1_16
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发表时间：
2018-01-01
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影响因子：
--
通讯作者：
Constantin, Lena
中科院分区：
文献类型：
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作者：
Constantin, Lena
环状RNA（circRNA）在大脑中丰富，并且通常以与不同的发育转变相一致的复杂时空模式表达。这表明circRNA在中枢神经系统中起着重要作用。本章将回顾circRNA在神经元发育中的功能的研究进展。将要讨论的主要主题是突触中circRNA的富集及其对突触病理学的可能贡献，此外还发现神经circRNA随着年龄的增长而积累，似乎有利于神经元修复。尽管还需要更多的研究，但circRNA在大脑中的一些可能功能已经开始显现。
Circular RNAs (circRNAs) are abundant in the brain and are often expressed in complex spatiotemporal patterns that coincide with distinct developmental transitions. This suggests that circRNAs play a significant role in the central nervous system. This book chapter will review research progress into the function of circRNAs during neuronal development. The major themes to be discussed are the enrichment of circRNAs in the synapse and their possible contributions to synaptopathologies, in addition to the findings that neural circRNAs accumulate with age and appear beneficial for neuronal repair. Although more research is needed, some of the possible functions of circRNAs with in the brain are already beginning to come to light.