Effects of biochemically confirmed smoking cessation on white blood cell count
Effects of biochemically confirmed smoking cessation on white blood cell count
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DOI：
10.4065/80.8.1022
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发表时间：
2005-08-01
影响因子：
8.9
通讯作者：
Rigotti, NA
中科院分区：
文献类型：
--
作者：
Abel, GA;Hays, JT;Rigotti, NA
目的：在一大批健康吸烟者中，确定白细胞(WBC)指标与几个基线变量之间的关系，并评估这些指标在生化确认戒烟后是否发生了变化。在基线、第7周和第52周测量WBC计数和中性粒细胞绝对计数(ANCs)。在第7周和52周通过自我报告和生化确认呼气一氧化碳水平来评估吸烟状况。多变量分析比较了不戒烟和不戒烟的吸烟者的白细胞计数和中性粒细胞的变化，调整了治疗组、年龄、性别和体重指数。结果：在784名纳入研究的吸烟者中，461人在服用安非他酮7周后生化确认戒烟；429人被随机分配继续接受安非他酮治疗或服用安慰剂，直到52周。在基线和第7周之间，持续戒烟者的白细胞计数比持续吸烟者的下降幅度要大得多(调整后的P=0.03)。在52周时，持续戒烟者与持续吸烟者相比，白细胞计数较基线有更大的下降(1.2+/-1.9x10(9)/L vs0.1+/-1.9x10(9)/L；P
OBJECTIVES: To determine the relationship between white blood cell (WBC) indices and several baseline variables in a large cohort of healthy smokers and to assess whether these changed after biochemically confirmed smoking cessation.SUBJECTS AND METHODS: The study consisted of 784 healthy smokers enrolled in a trial of sustained-release bupropion, 300 mg/d, for relapse prevention after smoking cessation from 1995 to 1998. Both WBC counts and absolute neutrophil counts (ANCs) were measured at baseline, week 7, and week 52. Smoking status was assessed at weeks 7 and 52 by self-report and biochemically confirmed with expired air carbon monoxide levels. Multivariate analyses compared changes in WBC count and ANC between smokers who did and did not stop smoking, adjusting for treat ment group, age, sex, and body mass index.RESULTS: Of 784 smokers enrolled, 461 had biochemically confirmed tobacco abstinence after 7 weeks of bupropion; 429 were randomly assigned to receive continued bupropion therapy or placebo until week 52. Between baseline and week 7, there was a significantly larger decrease in WBC count in continuously abstinent subjects compared with continuing smokers (adjusted P=.03). At 52 weeks, continuously abstinent subjects, compared with continuing smokers, had a greater decline from baseline in WBC count (1.2 +/- 1.9 x 10(9)/L vs 0.1 +/- 1.9 x 10(9)/L; P