CD25+CD4+T cells contribute to the control of memory CD8+T cells
CD25+CD4+T cells contribute to the control of memory CD8+T cells
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DOI：
10.1073/pnas.132254399
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发表时间：
2002-06-25
影响因子：
11.1
通讯作者：
Marrack, P
中科院分区：
文献类型：
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作者：
Murakami, M;Sakamoto, A;Marrack, P
以前我们证明了IL-15和IL-2控制小鼠中记忆性CD 8 + T细胞的数量。IL-15诱导，IL-2抑制这些细胞的分裂。在这里，我们表明，CD 25 + CD 4+调节性T细胞在IL-2介导的记忆表型CD 8 + T细胞数量的控制中发挥重要作用。在动物中，随着年龄的增长，CD 25 + CD 4 + T细胞的数量与记忆表型CD 8 + T细胞的数量呈负相关。用抗IL-2治疗引起CD 25 + CD 4 + T细胞消失，同时增加记忆表型CD 8 + T细胞的数量。CD 8+记忆表型T细胞数量的增加在缺乏CD 4+细胞的动物中并不明显。重要的是，CD 25 + CD 4 + T细胞的过继转移显著减少了记忆表型CD 8 + T细胞的分裂。因此，我们得出结论，CD 25 + CD 4 + T细胞参与IL-2介导的记忆性CD 8 + T细胞分裂的抑制，并且IL-2至少部分地通过维持CD 25 + CD 4 + T细胞群体来控制记忆性表型CD 8 + T细胞数量。
Previously we demonstrated that IL-15 and IL-2 control the number of memory CD8+ T cells in mice. IL-15 induces, and IL-2 suppresses the division of these cells. Here we show that CD25+CD4+ regulatory T cells play an important role in the IL-2-mediated control of memory phenotype CD8+ T cell number. in animals, the numbers of CD25+CD4+ T cells were inversely correlated with the numbers of memory phenotype CD8+ T cells with age. Treatment with anti-IL-2 caused CD25+CD4+ T cells to disappear and, concurrently, increased the numbers of memory phenotype CD8+ T cells. This increase in the numbers of CD8+ memory phenotype T cells was not manifest in animals lacking CD4+ cells. Importantly, adoptive transfer of CD25+CD4+ T cells significantly reduced division of memory phenotype CD8+ T cells. Thus, we conclude that CD25+CD4+ T cells are involved in the IL-2-mediated inhibition of memory CD8+ T cell division and that IL-2 controls memory phenotype CD8+ T cell numbers at least in part through maintenance of the CD25+CD4+ T cell population.