Metastasis Update: Human Prostate Carcinoma Invasion via Tubulogenesis.
Metastasis Update: Human Prostate Carcinoma Invasion via Tubulogenesis.
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DOI：
10.1155/2011/249290
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发表时间：
2011
期刊：
影响因子：
4.2
通讯作者：
Cress AE
中科院分区：
文献类型：
--
作者：
Nagle RB;Cress AE
本文提出，人类前列腺癌主要是通过类似于胚胎小管发生的机制作为一个粘性细胞集体入侵，而不是流行的上皮间质转化（EMT）模型。证据支持tubulogenesis模型，沿着建议进一步研究。此外，观察记录细胞粘附分子在组织和基质成分的变化进行审查，允许目前的分支形态模型和tubulogenesis模型之间的比较。最后，这个模型的影响，对侵略性前列腺疾病的治疗和诊断策略的流行观点。
This paper proposes that human prostate carcinoma primarily invades as a cohesive cell collective through a mechanism similar to embryonic tubulogenesis, instead of the popular epithelial-mesenchymal transformation (EMT) model. Evidence supporting a tubulogenesis model is presented, along with suggestions for additional research. Additionally, observations documenting cell adhesion molecule changes in tissue and stromal components are reviewed, allowing for comparisons between the current branching morphogenesis models and the tubulogenesis model. Finally, the implications of this model on prevailing views of therapeutic and diagnostic strategies for aggressive prostatic disease are considered.