Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19).
Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19).
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一名 11 岁女孩的胸腔内癌显示易位 t(15;19)。
DOI：
10.1097/00043426-199124000-00011
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
M. Willoughby
中科院分区：
文献类型：
--
作者：
U. Kees;M. Mulcahy;M. Willoughby
我们在此报告一位11岁女孩罕见的胸腔内未分化癌病例。活检组织用细胞角蛋白和癌胚抗原抗体染色。使用来自肿瘤的细胞系PER-403也获得了同样的染色。对PER-403细胞的DNA进行了EB病毒基因的检测，结果为阴性。细胞遗传学分析发现t(15；19)(p12；q13)易位，这是以前在癌症中未曾描述过的。
We report here a rare case of intrathoracic undifferentiated carcinoma in an 11-year-old girl. The biopsy tissue stained with antibodies against cytokeratin and carcino-embryonic antigen. The same staining was obtained using a cell line, PER-403, which was derived from the tumor. DNA from PER-403 cells was tested for the presence of Epstein-Barr virus genes, yielding a negative result. The cytogenetic analysis found a translocation t(15;19) (p12;q13), which has not previously been described in a carcinoma.