COMPARISON OF STREPTOCOCCUS-ZOOEPIDEMICUS AND INFLUENZA-VIRUS PATHOGENICITY IN MICE BY 3 PULMONARY EXPOSURE ROUTES
COMPARISON OF STREPTOCOCCUS-ZOOEPIDEMICUS AND INFLUENZA-VIRUS PATHOGENICITY IN MICE BY 3 PULMONARY EXPOSURE ROUTES
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DOI：
10.1128/aem.54.7.1744-1751.1988
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发表时间：
1988-07-01
影响因子：
4.4
通讯作者：
FENTERS, JD
中科院分区：
文献类型：
--
作者：
SHERWOOD, RL;THOMAS, PT;FENTERS, JD
使用几种接触途径可在实验动物中诱发肺部感染。微生物气溶胶的吸入通常被视为最相关的暴露途径，尽管鼻内（i.n.）或肠内愈合（i.t.）接种到雾化吸入还不清楚。在这些研究中，在i.n.，i.t.，或气雾剂激发。通过两种微生物的每种暴露途径确定50%致死剂量，并确定50%致死剂量的器官清除率。小鼠在i.n.或i.t.滴注与气雾剂激发相比。病毒或细菌的器官清除模式因接触途径而略有不同。
Pulmonary infections may be induced in experimental animals by using several exposure routes. Inhalation of microbial aerosols is often viewed as the most relevant exposure route, although the comparability of either intranasal (i.n.) or intratracheal (i.t.) inoculation to aerosol inhalation is unclear. In these studies, the infection of mice with either Streptococcus zooepidemicus or influenza virus was compared following i.n., i.t., or aerosol challenge. The 50% lethal dose was determined by each exposure route for both microbes, and the organ clearance of a 50% lethal dose was determined. Mice were as or more sensitive to bacterial or viral infection following i.n. or i.t. instillation as compared with aerosol challenge. Organ clearance patterns of virus or bacteria varied slightly with exposure route.