Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "Click" chemistry
Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "Click" chemistry
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DOI：
10.1021/ja8006325
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发表时间：
2008-04-16
影响因子：
15
通讯作者：
Hawker, Craig J.
中科院分区：
文献类型：
--
作者：
Killops, Kato L.;Campos, Luis M.;Hawker, Craig J.
通过发散生长策略，使用硫醇-烯“点击”化学和传统的酯化反应的组合，成功地制备了树枝状大分子到第四代。硫醇-烯反应在无溶剂的环境条件下在室温下通过用UV光照射进行。第四代树枝状聚合物随后通过硫醇-烯反应用羧酸、芘和Fmoc保护的半胱氨酸部分官能化。
Dendrimers up to the fourth generation were successfully prepared via the divergent growth strategy using a combination of thiol-ene "click" chemistry and traditional esterification reactions. The thiol-ene reactions were conducted under solvent-free, ambient conditions at room temperature by irradiating with UV light. The fourth-generation dendrimers were subsequently functionalized with carboxylic acid, pyrene, and Fmoc-protected cysteine moieties via thiol-ene reactions.