The Clinical Application Value of RDW, CA153, and MPV in Breast Cancer
The Clinical Application Value of RDW, CA153, and MPV in Breast Cancer
复制标题
RDW、CA153、MPV在乳腺癌中的临床应用价值
DOI：
10.7754/clin.lab.2020.200507
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发表时间：
2021-01-01
影响因子：
0.7
通讯作者：
Wang, Jian
中科院分区：
文献类型：
--
作者：
Lu, Fengke;Pan, Siqiong;Wang, Jian
背景：肿瘤的早期发现有利于患者的治疗。血液常规中的某些指标，如红细胞分布宽度（RDW），被认为是用来评估患者的病情和预后。平均血小板体积（MPV）也用于评估患者的预后。糖类抗原153（CA 153）被认为是乳腺癌更特异的抗原标志物。本研究旨在探讨RDW、MPV、CA 153对乳腺癌（BC）和乳腺增生（BH）的诊断价值。通过自动电化学发光分析仪（Cobas e601，Roche Diagnostics，Switzerland）检测CA 153。结果：与乳腺增生组比较，乳腺癌组血清RDW、CA 153均升高，差异有统计学意义（P < 0. 05）。健康对照组、乳腺增生组、乳腺癌组RDW、CA 153均呈正相关。Logistic回归结果显示，年龄增加、RDW增加、CA 153增加可增加乳腺癌的危险性。ROC曲线下面积（AUC）分析显示，联合应用RDW、MPV和CA 153对乳腺癌的诊断特异性和敏感性均优于单一指标。结论：联合应用RDW、MPV和CA 153可提高乳腺癌与乳腺增生的鉴别诊断水平。
Background: Early detection of tumors is beneficial to the treatment of patients. Certain indicators in the blood routine, such as red blood cell distribution width (RDW), are considered to be used to assess the patient's condition and prognosis. Mean platelet volume (MPV) is also used to assess the prognosis of patients. Carbohydrate antigen 153 (CA153) is considered to be a more specific antigen marker for breast cancer. The purpose of our study was to explore the diagnostic value of RDW, MPV, and CA153 for breast cancer (BC) and breast hyperplasia (BH).Methods: The study included 104 breast cancer patients, 100 breast hyperplasia patients, and 100 healthy controls. CA153 was detected by an automatic electrochemical luminescence analyzer (Cobas e601, Roche Diagnostics, Switzerland). The concentration of RDW and MPV in serum was measured by Sysmex XN-10-B3 (Sysmex, Japan).Results: Compared with the breast hyperplasia group, the RDW and CA153 of the breast cancer group were increased. The healthy control group, mammary gland hyperplasia group, and breast cancer were positively correlated with RDW and CA153. Logistic regression results show that increasing age, increasing RDW, and increasing CA153 can increase the risk of breast cancer. The area under the ROC (AUC) analysis showed that the combined specificity and sensitivity of the combined application of RDW, MPV, and CA153 for the identification of breast cancer is better than that of a single marker.Conclusions: The combined application of RDW, MPV, and CA153 can improve the differential diagnosis of breast cancer and breast hyperplasia.