Immunological consequences of arthropod vector-derived salivary factors
Immunological consequences of arthropod vector-derived salivary factors
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DOI：
10.1002/eji.201190075
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发表时间：
2011-12-01
影响因子：
5.4
通讯作者：
Wali, Tonu
中科院分区：
文献类型：
--
作者：
Leitner, Wolfgang W.;Costero-St Denis, Adriana;Wali, Tonu
疟疾、登革热、利什曼病和蜱传脑炎等疾病影响世界相当大比例的人口，并继续导致大量发病和死亡。这些疾病的一个共同方面是，引起它们的病原体通过受感染的节肢动物（例如蚊子，白蛉，蜱）的叮咬传播。病原体与节肢动物唾液沿着被递送到哺乳动物宿主的皮肤中，节肢动物唾液含有多种生物活性分子。这些唾液成分能够改变止血和免疫反应，并可能有助于病原体建立感染的能力。病原体传播过程中发生的生物学和免疫学事件知之甚少，但可能是预防传播和/或感染的新方法的关键。2011年5月，美国卫生与公众服务部国家卫生研究院（NIH）的国家过敏和传染病研究所（NIAID）主办了一个题为“媒介衍生因子的免疫学后果”的研讨会，该研讨会汇集了皮肤免疫学、寄生虫学和媒介生物学方面的专家，概述了我们对病原体传播过程的理解方面的差距，探索控制病原体传播的新方法，并启动和促进这些研究人员之间的多学科合作。
Diseases, such as malaria, dengue, leishmaniasis and tick-borne encephalitis, affect a substantial percentage of the world's population and continue to result in significant morbidity and mortality. One common aspect of these diseases is that the pathogens that cause them are transmitted by the bite of an infected arthropod (e.g. mosquito, sand fly, tick). The pathogens are delivered into the skin of the mammalian host along with arthropod saliva, which contains a wide variety of bioactive molecules. These saliva components are capable of altering hemostasis and immune responses and may contribute to the ability of the pathogen to establish an infection. The biological and immunological events that occur during pathogen transmission are poorly understood but may hold the key to novel approaches to prevent transmission and/or infection. In May 2011, the National Institute of Allergy and Infectious Diseases (NIAID) of the US National Institutes of Health (NIH) in the Department of Health and Human Services hosted a workshop entitled Immunological Consequences of Vector-Derived Factors which brought together experts in skin immunology, parasitology and vector biology to outline the gaps in our understanding of the process of pathogen transmission, to explore new approaches to control pathogen transmission, and to initiate and foster multidisciplinary collaborations among these investigators.