Construction of Hyaluronic Tetrasaccharide Clusters Modified Polyamidoamine siRNA Delivery System.
Construction of Hyaluronic Tetrasaccharide Clusters Modified Polyamidoamine siRNA Delivery System.
复制标题
透明质酸四糖簇修饰聚酰胺胺siRNA递送系统的构建
DOI：
10.3390/nano8060433
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发表时间：
2018-06-14
期刊：
影响因子：
--
通讯作者：
Qi XR
中科院分区：
文献类型：
--
作者：
Ma Y;Sha M;Cheng S;Yao W;Li Z;Qi XR
The CD44 protein, as a predominant receptor for hyaluronan (HA), is highly expressed on the surface of multiple tumor cells. HA, as a targeting molecule for a CD44-contained delivery system, increases intracellular drug concentration in tumor tissue. However, due to the weak binding ability of hyaluronan oligosaccharide to CD44, targeting for tumor drug delivery has been restricted. In this study, we first use a HA tetrasaccharide cluster as the target ligand to enhance the binding ability to CD44. A polyamidoamine (PAMAM) dendrimer was modified by a HA tetrasaccharide cluster as a nonviral vector for small interfering RNA (siRNA) delivery. The dendrimer/siRNA nanocomplexes increased the cellular uptake capacity of siRNA through the CD44 receptor-mediated endocytosis pathway, allowing the siRNA to successfully escape the endosome/lysosome. Compared with the control group, nanocomplexes effectively reduced the expression of GFP protein and mRNA in MDA-MB-231-GFP cells. This delivery system provides a foundation to increase the clinical applications of PAMAM nanomaterials.
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影响因子：
2.5
作者：
Chen, Daquan;Song, Xiaoyan;Zhao, Feng
通讯作者：
Zhao, Feng
影响因子：
4.5
作者：
Patel, Satish Kumar;Gajbhiye, Virendra;Jain, Narendra Kumar
通讯作者：
Jain, Narendra Kumar
影响因子：
9.5
作者：
Tambe, Prajakta;Kumar, Pramod;Gajbhiye, Virendra
通讯作者：
Gajbhiye, Virendra
用于抗血管生成和细胞凋亡联合治疗的肿瘤靶向和微环境响应型智能纳米颗粒
影响因子：
17.1
作者：
Huang, Shixian;Shao, Kun;Jiang, Chen
通讯作者：
Jiang, Chen
影响因子：
16.8
作者：
Banerji, Suneale;Wright, Alan J.;Jackson, David G.
通讯作者：
Jackson, David G.