Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010
Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010
复制标题
DOI：
10.1093/neuonc/now252
复制
发表时间：
2017-05-01
期刊：
影响因子：
15.9
通讯作者：
Barnholtz-Sloan, Jill S.
中科院分区：
文献类型：
--
作者：
Zhang, Adah S.;Ostrom, Quinn T.;Barnholtz-Sloan, Jill S.
完整的患病率比例说明了人口中的疾病负担。这项研究估计了2010年恶性原发性脑肿瘤的总体和美国中央脑肿瘤登记处（CBTRUS）组织学组的完全患病率，并将脑肿瘤患病率估计值与其他常见癌症的完全患病率进行了比较，这些癌症由监测，流行病学和最终结果计划（SEER）确定，按患病年龄（2010年）：儿童（0-14岁）、青少年和年轻成人（AYA）（15-39岁）和成人（40岁以上）。使用从完整性指数方法扩展的新回归方法估计完全患病率比例，该方法结合了来自多个来源的生存和发病率数据。在这项研究中，两个数据集，CBTRUS和SEER，被用来计算感兴趣的完全患病率估计。恶性原发性脑肿瘤的完全患病率为47.59/100000人口（22.31，48.49，和57.75/100000的儿童，AYA和成人人群）。最常见的癌症是儿童白血病（36.65/100000），皮肤AYA黑色素瘤（66.21/100000）和成年女性乳腺癌（1949.00/100000）。儿童和AYA中最常见的CBTRUS组织学类型为毛细胞性星形细胞瘤（6.82/100000，5.92/100000），成人中为胶质母细胞瘤（12.76/100000）。儿童中恶性原发性脑肿瘤的相对影响高于任何其他年龄组;它是儿童中第二常见的癌症。原发性恶性脑肿瘤的完整患病率估计填补了整体癌症知识的空白，为公共卫生和医疗保健规划提供了关键信息，包括治疗，决策，资金和宣传计划。
Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0-14 y), adolescent and young adult (AYA) (15-39 y), and adult (40+ y).Complete prevalence proportions were estimated using a novel regression method extended from the Completeness Index Method, which combines survival and incidence data from multiple sources. In this study, two datasets, CBTRUS and SEER, were used to calculate complete prevalence estimates of interest.Complete prevalence for malignant primary brain tumors was 47.59/100000 population (22.31, 48.49, and 57.75/100000 for child, AYA, and adult populations). The most prevalent cancers by age were childhood leukemia (36.65/100000), AYA melanoma of the skin (66.21/100000), and adult female breast (1949.00/100000). The most prevalent CBTRUS histologies in children and AYA were pilocytic astrocytoma (6.82/100000, 5.92/100000), and glioblastoma (12.76/100000) in adults.The relative impact of malignant primary brain tumors is higher among children than any other age group; it emerges as the second most prevalent cancer among children. Complete prevalence estimates for primary malignant brain tumors fills a gap in overall cancer knowledge, which provides critical information toward public health and health care planning, including treatment, decision making, funding, and advocacy programs.