Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation
Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation
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DOI：
10.1161/01.atv.0000077401.36885.bb
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发表时间：
2003-07-01
影响因子：
8.7
通讯作者：
Juhan-Vague, I
中科院分区：
文献类型：
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作者：
Alessi, MC;Bastelica, D;Juhan-Vague, I
由于肥胖和胰岛素抵抗（IR）与肝脏脂肪变性（LS）密切相关，我们研究了ob/ob小鼠、酒精性LS的C57/BL 6小鼠和严重肥胖的人中LS和纤溶酶原激活物抑制剂-1（派-1）程度之间的关系。血浆派-1水平与肝组织派-1表达及LS程度相关。肝脏派-1抗原与肿瘤坏死因子受体II（TNFRII）抗原相关，而与TNF抗原含量的关联仅见于ob/ob小鼠。ob/ob小鼠血浆派-1与脂肪组织派-1表达无明显相关性。此外，ob/ob小鼠血浆派-1水平与体重呈正相关，而C57/BL 6小鼠血浆PAI-1水平与体重呈负相关（均P
Objective-Because obesity and insulin resistance (IR) are strongly associated with liver steatosis (LS), we investigated the relation between the degree of LS and plasminogen activator inhibitor-1 (PAI-1) in ob/ob mice, in C57/BL6 mice with alcoholic LS, and in severely obese humans.Methods and Results-In both mouse models, plasma PAI-1 levels were associated with PAI-1 expression in the liver and with the degree of LS. Liver PAI-1 antigen was associated with the tumor necrosis factor receptor-II (TNFRII) antigen, whereas association with TNF antigen content was found in ob/ob mice only. No significant correlation between plasma PAI-1 and PAI-1 expression in adipose tissue of ob/ob mice was observed. Furthermore, the relation between plasma PAI-1 levels and body weight was positive in ob/ob mice but negative in C57/BL6 mice (both P