Lymphocytes are important in early atherosclerosis.
Lymphocytes are important in early atherosclerosis.
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DOI：
10.1172/jci11380
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发表时间：
2001-07
期刊：
影响因子：
--
通讯作者：
Li Song;C. Leung;C. Schindler
中科院分区：
文献类型：
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作者：
Li Song;C. Leung;C. Schindler
淋巴细胞是一种潜在的重要的促炎细胞，定位于动脉粥样硬化病变。为了确定它们是否有助于病变的发展，将易患动脉粥样硬化(LDLR(-/-))的小鼠与淋巴细胞缺陷(RAG1(-/-))小鼠杂交，以产生双基因敲除后代。在西式饮食(WTD)8周后，与匹配的LDLR(-/-)对照组相比，双基因敲除小鼠的病变发展减少了54%。然而，随着WTD的持续12周和16周，病变面积的这些显著差异逐渐消失。与此观察一致的是，组织学研究确定RAG1/LDL-R双基因敲除小鼠的病变起始和早期进展延迟。病变面积的差异与血脂水平的任何显著变化无关。这些研究表明，淋巴细胞在动脉粥样硬化形成的早期起着重要作用。
Lymphocytes represent a potentially important proinflammatory cell that localizes to atherosclerotic lesions. To determine whether they contribute to lesion development, atherosclerosis-prone (LDLR(-/-)) mice were crossed with lymphocyte-deficient (RAG1(-/-)) mice to generate double knockout progeny. After 8 weeks on a Western-type diet (WTD), lesion development was reduced by 54% in double knockout mice, as compared with matched LDLR(-/-) controls. However, these significant differences in lesion area gradually subsided as the WTD was continued for 12 and 16 weeks. Consistent with this observation, histological studies determined that lesion initiation and early progression were delayed in RAG1/LDL-R double knockout mice. Differences in lesion area did not correlate with any significant alterations in plasma lipid levels. These studies suggest that lymphocytes play an important role early in atherogenesis.