Circadian rhythms in the blood-brain barrier: impact on neurological disorders and stress responses.
Circadian rhythms in the blood-brain barrier: impact on neurological disorders and stress responses.
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DOI：
10.1186/s13041-023-00997-0
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发表时间：
2023-01-12
期刊：
影响因子：
3.6
通讯作者：
Toborek, Michal
中科院分区：
文献类型：
--
作者：
Schurhoff, Nicolette;Toborek, Michal
由于轮班工作、睡眠中断、蓝光暴露和通过不同时区旅行的增加，昼夜节律紊乱在社会中变得更加普遍。昼夜节律是一个定时的转录-翻译反馈回路，具有正调节因子BMAL 1和CLOCK，它们与负调节因子CRY和PER相互作用，以调节中枢和外周时钟。这篇综述强调了昼夜节律的功能，特别是在血脑屏障（BBB），在健康和病理状态。BBB是由CNS内皮细胞、星形胶质细胞、周细胞、神经元和小胶质细胞组成的高选择性动态界面，其形成神经血管单位（NVU）。昼夜节律通过调节紧密连接蛋白的振荡、辅助NVU的功能和调节转运蛋白功能来调节BBB完整性。在应激反应和几种神经系统疾病中已经观察到BBB内的昼夜节律中断，包括脑转移、癫痫、阿尔茨海默病和帕金森病。进一步了解这些相互作用可能有助于改进治疗方案和预防措施的发展。
Circadian disruption has become more prevalent in society due to the increase in shift work, sleep disruption, blue light exposure, and travel via different time zones. The circadian rhythm is a timed transcription-translation feedback loop with positive regulators, BMAL1 and CLOCK, that interact with negative regulators, CRY and PER, to regulate both the central and peripheral clocks. This review highlights the functions of the circadian rhythm, specifically in the blood–brain barrier (BBB), during both healthy and pathological states. The BBB is a highly selective dynamic interface composed of CNS endothelial cells, astrocytes, pericytes, neurons, and microglia that form the neurovascular unit (NVU). Circadian rhythms modulate BBB integrity through regulating oscillations of tight junction proteins, assisting in functions of the NVU, and modulating transporter functions. Circadian disruptions within the BBB have been observed in stress responses and several neurological disorders, including brain metastasis, epilepsy, Alzheimer’s disease, and Parkinson’s disease. Further understanding of these interactions may facilitate the development of improved treatment options and preventative measures.
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影响因子：
16.6
作者：
Barca-Mayo O;Pons-Espinal M;Follert P;Armirotti A;Berdondini L;De Pietri Tonelli D
通讯作者：
De Pietri Tonelli D
影响因子：
5.1
作者：
Cai, Y.;Liu, S.;Chan, P.
通讯作者：
Chan, P.
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
衰老和痴呆症中的睡眠障碍
影响因子：
5.8
作者：
Bombois, S.;Derambure, P.;Monaca, C.
通讯作者：
Monaca, C.
影响因子：
5.6
作者：
Chan F;Liu J
通讯作者：
Liu J