The minimum dose of acarbose suppresses triglyceride concentration in remnant-like particles from fasted diabetic subjects.
The minimum dose of acarbose suppresses triglyceride concentration in remnant-like particles from fasted diabetic subjects.
复制标题
阿卡波糖的最小剂量可抑制来自禁食糖尿病受试者的残余样颗粒中的甘油三酯浓度。
DOI：
10.1055/s-2007-979806
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
T. Urayama
中科院分区：
文献类型：
--
作者：
G. Yoshino;S. Furukawa;T. Hirano;H. Naito;T. Kazumi;T. Urayama
A recent report (2) has confirmed the association between ele-vated plasma levels of intestinally derived triglyceride-rich lipoproteins and coronary artery disease. Acarbose, a potent intestinal glucosidase inhibitor, reduces the availability of glucose for intestinal absorption and, therefore, suppresses postprandial plasma glucose and insulin levels in diabetic subjects (5). It has also been reported that postprandial triglyceride levels can be reduced by acarbose treatment (1). Thus, we examined the effect of acarbose on plasma lipid levels, especially on remnant-like particles (RLP, lipoproteins without apolipo-protein A3 and B100) in non-insulin dependent diabetic subjects (NIDDM).Thirty-one NIDDM patients (15 male, 16 female: 24 on diet, 7 on sulfonylureas) aged 51(SD) years were studied. After more than 3 months of stabilized blood glucose control, acarbose (150 mg/day in 3 divided doses) was administered for one month. Separation of RLP fraction from whole plasma was achieved by using an immunoaffinity column containing antihuman apolipoproteins (apo) A1 and B100 monoclonal antibodies (3). The characterization of unbound fractions has shown that they represent chylomicron and VLDL remnant-like par-ticles.
