Concordance of disease form in kindreds ascertained through affected individuals
Concordance of disease form in kindreds ascertained through affected individuals
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DOI：
10.1002/sim.988
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发表时间：
2002-07-15
影响因子：
2
通讯作者：
Rabinowitz, D
中科院分区：
文献类型：
--
作者：
Winawer, M;Ottman, R;Rabinowitz, D
当设计或进行一种具有几种不同形式的疾病的遗传流行病学研究时，了解不同形式的易感性是否由不同基因赋予，或者是否存在赋予多种形式易感性的基因是有用的。探索这些问题的一个自然方法是研究疾病如何在运动中形成集群。然而，当纳入研究是基于多个亲属的情感状态时，疾病形式的家族聚集性的扭曲模式可能是明显的。这里的目的是提出调整这种失真的统计方法。特别是，方法来测试两个零假设：一个零假设，对应于所有基因以相同的方式对不同的疾病形式的相对风险的作用，和一个零假设，对应于每个基因赋予不同的疾病形式的易感性，说明通过应用程序的方法的广义和本地化相关形式的癫痫。版权所有（C）2002约翰威利父子有限公司
When designing or conducting genetic epidemiological studies of a disease with several distinct forms, it is useful to know whether susceptibilities to the different forms are conferred by different genes or whether there are genes that confer susceptibility to multiple forms. A natural approach to exploring these issues is to examine how the disease forms cluster in kindreds. When inclusion in the study is based on the affection status of multiple relatives, however, distorted patterns of familial clustering of disease form can be evident. The purpose here is to present statistical methods for adjusting for this distortion. In particular, approaches to testing two null hypotheses are presented: a null hypothesis that corresponds to all genes acting in the same way on the relative risk of the different disease forms, and a null hypothesis that corresponds to each gene conferring susceptibility to distinct disease forms, The approaches are illustrated through an application to the generalized and localization-related forms of epilepsy. Copyright (C) 2002 John Wiley Sons, Ltd.