Single blastocyst transfer: a prospective randomized trial
Single blastocyst transfer: a prospective randomized trial
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DOI：
10.1016/j.fertnstert.2003.07.023
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发表时间：
2004-03-01
影响因子：
6.7
通讯作者：
Schoolcraft, WB
中科院分区：
文献类型：
--
作者：
Gardner, DK;Surrey, E;Schoolcraft, WB
目的：探讨单囊胚移植的疗效。设计：前瞻性随机试验。单位：私人辅助生殖技术单位。患者：48例接受体外受精胚胎移植的妇女，第3天FSH小于或等于10 mIU/mL，在给予hCG当天至少有10个卵泡直径为12毫米。干预：胚胎在顺序培养基G1/G2中培养至囊胚期，然后移植一个或两个囊胚。主要观察指标：着床率、持续妊娠率、双胞胎数。结果：单囊胚移植成功着床，妊娠率为60.9%，无双胞胎。两个囊胚移植的着床率为56%，持续妊娠率为76%，双胞胎发生率为47.4%。结论：单囊胚移植是一种有效的消除多胎的方法，同时保持高妊娠率。
Objective: To determine the efficacy of single blastocyst transfer.Design: Prospective randomized trial.Setting: Private assisted reproductive technology unit.Patient(s): Forty-eight women undergoing IVF-embryo transfer with day 3 FSH less than or equal to 10 mIU/mL and at least 10 follicles >12 mm in diameter on day of hCG administration.Intervention(s): Embryo culture to the blastocyst stage in sequential media G1/G2 followed by transfer of either one or two blastocysts.Main Outcome Measure(s): Implantation rate, ongoing pregnancy rate, and twinning.Result(s): The transfer of a single blastocyst resulted in an implantation and ongoing pregnancy rate of 60.9% with no twins. The transfer of two blastocysts resulted in an implantation rate of 56%, an ongoing pregnancy rate of 76% with a 47.4% incidence of twins.Conclusion(s): Single blastocyst transfer is an effective method of eliminating multiple births while maintaining high pregnancy rates in this selected group of patients.