Quality of life in multiple sclerosis: the impact of depression, fatigue and disability
Quality of life in multiple sclerosis: the impact of depression, fatigue and disability
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DOI：
10.1177/135245850100700511
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发表时间：
2001-10-01
影响因子：
5.8
通讯作者：
Rossi, L
中科院分区：
文献类型：
--
作者：
Amato, MP;Ponziani, G;Rossi, L
本研究对103例多发性硬化（MS）患者（37例男性，66例女性;平均年龄44.89岁，平均病程12.40年;平均EDSS评分4.07）的生活质量及其主要临床和人口统计学决定因素进行了评估。我们使用了MSQOL-54清单，这是一种最近在意大利人群中验证的疾病特异性工具。所有患者均接受完整的临床评估，包括残疾状态（扩展残疾状态量表）、认知功能（简易精神状态检查）、抑郁（汉密尔顿抑郁量表）和疲劳（疲劳严重程度量表）。在皮尔逊相关性方面，残疾程度和MSQOL-54身体综合评分之间呈中度负相关，抑郁或疲劳严重程度与身体和精神综合评分之间呈中度至强负相关。在逐步线性回归分析中，抑郁，疲劳和残疾程度被证实是生活质量的显着和独立的预测因子。生活质量工具可以帮助提供更广泛的疾病影响测量，并制定适合患者需求的护理计划。
This study deals with the assessment of quality of life and its main clinical and demographical determinants in a clinical series of 103 patients with multiple sclerosis (MS) (37 men; 66 women; mean age 44.89 years, mean disease duration 12.40 years; mean EDSS score 4.07). We used the MSQOL-54 inventory, a disease-specific instrument recently validated in an Italian population. Each patient underwent a complete clinical assessment including that of disability status (Expanded Disability Status Scale), cognitive function (Mini Mental State Examination), depression (Hamilton Rating Scale for Depression) and fatigue (Fatigue Severity Scale). In terms of Pearson's correlations, there was a moderate inverse relationship between disability level and the MSQOL-54 physical composite score, and a moderate to strong inverse correlation between depression or fatigue severity and both the physical and mental composite scores. In a stepwise linear regression analysis, depression, fatigue and disability level were confirmed to be significant and independent predictors of quality of life. Quality of life instruments can help to provide a broader measure of the disease impact and to develop a care program tailored to the patient's needs.