The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression
The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression
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DOI：
10.1016/s1078-1439(03)00015-2
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发表时间：
2004-01-01
影响因子：
2.7
通讯作者：
Yeh, WM
中科院分区：
文献类型：
--
作者：
Yang, CC;Chu, KC;Yeh, WM
血管上皮生长因子（VEGF）调节恶性细胞的新血管形成。 VEGF 作为有丝分裂原被认为可以改变癌细胞的形成和肿瘤进展。我们的目的是研究 VEGF 基因的表达，以评估其在膀胱移行细胞癌 (TCC) 中的临床意义。使用免疫组织化学染色检查 161 名 TCC 患者的组织样本中 VEGF 基因的表达情况。将表达率与从非癌症患者经尿道手术获得的 32 个正常膀胱粘膜样本进行比较。结果显示，正常尿路上皮（0%）和癌组织（54.7%）的VEGF蛋白阳性染色存在显着差异（P < 0.001）。随着肿瘤分级和临床分期的进展，VEGF基因表达阳性率显着升高。侵袭组VEGF基因表达高于非侵袭组（P < 0.001）。结果显示，VEGF基因的表达与TCC的形成和进展成正比。因此，VEGF基因的异常表达可作为膀胱TCC的预后标志物。 (C) 2004 Elsevier Inc. 保留所有权利。
Vascular epithelial growth factor (VEGF) regulates neovascualrization in malignant cells. VEGF as a mitogen is thought to alter cancer cell formation and tumor progression. We aimed to investigative the expression of the VEGF gene to evaluate their clinical significance in transitional cell carcinoma (TCC) of urinary bladder. Tissue samples from 161 patients with TCC were examined with an immunohistochemical stain for the expression of the VEGF gene. The expression rate was compared to 32 normal bladder mucosal samples obtained from transurehtral surgery from noncancer patients. The results revealed significant differences between normal urothelium (0%) and cancer tissue (54.7%) for the positive staining of VEGF protein (P < 0.001). With the progression of tumor grade and clinical staging, the positive rate of VEGF gene expression significantly increased. Expression of the VEGF gene in the invasive group was greater than that in the noninvasive group (P < 0.001). The results revealed that expression of the VEGF gene is proportional to the formation and progression of TCC. Therefore, abnormal expression of VEGF genes can be used as a prognostic marker in TCC of urinary bladder. (C) 2004 Elsevier Inc. All rights reserved.