Electrophysiological effects of remodeling cardiac gap junctions and cell size - Experimental and model studies of normal cardiac growth
Electrophysiological effects of remodeling cardiac gap junctions and cell size - Experimental and model studies of normal cardiac growth
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DOI：
10.1161/01.res.86.3.302
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发表时间：
2000-02-18
影响因子：
20.1
通讯作者：
Barr, RC
中科院分区：
文献类型：
--
作者：
Spach, MS;Heidlage, JF;Barr, RC
结构性心脏病心律失常的发生率增加，伴随着间隙连接的细胞分布的重塑，如新生儿心肌细胞的弥漫性模式。因此，了解由于正常生长肥大导致的间隙连接的重塑如何改变与在宏观水平测量的传导速度相关的细胞水平上的各向异性传播（（V）/点（max））变得重要。为此，间隙连接（connexin 43）的形态学研究和体外电测量进行了新生儿和成年犬心室肌。在电学上，正常生长的心肌细胞在宏观和微观水平上产生不同的变化模式。虽然纵向和横向传导速度在成人大于新生儿肌肉，各向异性速度比是相同的。在新生儿中，在纵向（LP）和横向（TP）传播过程中，点（max）上的平均值（V）没有差异。然而，生长肥大导致平均TP（V）选择性增加，而不是dot（max）（P
The increased incidence of arrhythmias in structural heart disease is accompanied by remodeling of the cellular distribution of gap junctions to a diffuse pattern like that of neonatal cardiomyocytes. Accordingly, it has become important to know how remodeling of gap junctions due to normal growth hypertrophy alters anisotropic propagation at a cellular level ((V) over dot(max)) in relation to conduction velocities measured at a macroscopic level. To this end, morphological studies of gap junctions (connexin43) and in vitro electrical measurements were performed in neonatal and adult canine ventricular muscle. When cells enlarged, gap junctions shifted from the sides to the ends of ventricular myocytes, Electrically, normal growth produced different patterns of change at a macroscopic and microscopic level. Although the longitudinal and transverse conduction velocities were greater in adult than neonatal muscle, the anisotropic velocity ratios were the same. In the neonate, mean (V) over dot(max) was not different during longitudinal (LP) and transverse (TP) propagation. However, growth hypertrophy produced a selective increase in mean TP (V) over dot(max) (P