ENDOTHELIALIZATION OF POLYMER SURFACES
ENDOTHELIALIZATION OF POLYMER SURFACES
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DOI：
10.1002/jbm.820220403
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发表时间：
1988-04-01
期刊：
影响因子：
--
通讯作者：
CHANG, G
中科院分区：
文献类型：
--
作者：
ABSOLOM, DR;HAWTHORN, LA;CHANG, G
研究了基材表面性质在影响聚合物表面内皮化程度中所起的作用。对于广泛的聚合物表面，猪和牛内皮细胞的内皮化程度与聚合物表面张力直接相关：内皮化程度随着基质表面张力的增加而增加。由于蛋白质在培养介质中的吸附，聚合物的表面性质发生了很大的变化。在非变性条件下，通过液-液接触角测量对蛋白质包覆聚合物进行了表征。内皮化程度与测量的葡聚糖接触角之间存在显著的相关性。内皮细胞铺展程度与聚合物表面张力无关。然而，细胞形态和细胞外基质的产生受到底物表面性质的影响。
The role tha substrate surface properties play in influencing the extent of endothelialization of polymer surfaces has been investigated. For a wide range of polymer surfaces, the degree of endothelialization for both porcine and bovine endothelial cells is directly related to polymer surface tension: increased endothelialization occurring with increasing substrate surface tension. As a result of adsorption of the proteins in the culture media, the surface properties of the polymers are altered considerably. The protein-coated polymers were characterized by means of liquid-liquid contact angle measurements under non-denaturing conditions. A striking correlation is observed between the degree of endothelialization and the measured dextran contact angle. The degree of endothelial cell spreading is not related to polymer surface tension. Cell morphology and extracellular matrix production, however, are influenced by substrate surface properties.