Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
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DOI：
10.1016/j.ijcard.2004.12.025
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发表时间：
2005-10-20
影响因子：
3.5
通讯作者：
Stefanadis, C
中科院分区：
文献类型：
--
作者：
Aggeli, C;Antoniades, C;Stefanadis, C
背景：重型β-地中海贫血与心血管风险增加相关，但其潜在机制尚不清楚。我们研究了内皮功能和输血依赖型β-地中海贫血major.Methods：研究人群包括67例纯合子β-地中海贫血重型患者（年龄24.6 +/- 0.7岁）和71名健康的年龄和性别匹配的对照组的炎症介质的血清水平。前臂血流量测量应变容积描记术。前臂对反应性充血（RH%）或硝酸盐（NTG%）的血管舒张反应分别表示为前臂血流从基线到反应性充血或舌下含服硝酸甘油期间最大血流的百分比变化。结果：患者血清总胆固醇水平（125 ± 4.5 vs 207 ± 7 mg/ml，P < 0.01）明显低于正常对照组（P < 0.01），血清白细胞介素6（IL-6）、可溶性血管细胞粘附分子1（sVCAM-1）和可溶性细胞间粘附分子1（sICAM-1）水平明显低于正常对照组（P < 0.01），差异有统计学意义（P < 0.05）。
Background: Beta-thalassemia major is associated with increased cardiovascular risk, although the underlying mechanisms remain unclear. We examined endothelial function and serum levels of inflammatory mediators in trans fusion-dependent patients with beta-thalassemia major.Methods: The study population consisted of 67 patients with homozygous beta-thalassemia major, (aged 24.6 +/- 0.7 years) and 71 healthy age and sex matched controls. Forearm blood flow was measured with gauge-strain plethysmography. Forearm vasodilatory response to reactive hyperemia (RH%) or to nitrate (NTG%) was expressed as the percentage change of forearm blood flow from baseline to the maximum flow during reactive hyperemia or sublingual nitroglycerin, respectively. Serum levels of interleukin 6 (IL-6), soluble vascular cell adhesion molecule (sVCAM-1) and soluble intercellular adhesion molecule (sICAM-1) were determined with ELISA.Results: Patients had significantly lower levels of total cholesterol (125 +/- 4.5 vs. 207 +/- 7 mg/ml, p