Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors
Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors
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DOI：
10.1016/j.virusres.2008.01.002
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发表时间：
2008-06-01
期刊：
影响因子：
5
通讯作者：
Tachedjian, Gilda
中科院分区：
文献类型：
--
作者：
Sluis-Cremer, Nicolas;Tachedjian, Gilda
The non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are a therapeutic class of compounds that are routinely used, in combination with other antiretroviral drugs, to treat HIV-1 infection. NNRTIs primarily block HIV-1 replication by preventing RT from completing reverse transcription of the viral single-stranded RNA genome into DNA. However, some NNRTIs, such as efavirenz, have been shown to inhibit the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing, while others, such as the pyrimidinediones, have been shown to inhibit both HIV-1 RT-mediated reverse transcription and HIV-1/HIV-2 viral entry. Accordingly, in this review we describe the multiple mechanisms by which NNRTIs inhibit HIV-1 reverse transcription (and in some cases HIV-2 reverse transcription) and other key steps involved in HIV-1/HIV-2 replication. (C) 2008 Elsevier B.V. All rights reserved.
