SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells
SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells
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DOI：
10.1038/s41375-020-0887-9
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发表时间：
2020-06-01
期刊：
影响因子：
11.4
通讯作者：
Kucia, Magda
中科院分区：
文献类型：
--
作者：
Ratajczak, Mariusz Z.;Kucia, Magda
科学界面临着与SARS-CoV-2大流行相关的意想不到的紧迫挑战，他们正在研究参与这种病毒进入细胞的受体的作用，以及导致细胞因子“风暴”的病理机制，在许多情况下，细胞因子“风暴”最终导致严重急性呼吸综合征、暴发性心肌炎和肾损伤。一个重要的问题是，它是否也可能损害造血干细胞祖细胞？
The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine "storm," which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis and kidney injury. An important question is if it may also damage hematopoietic stem progenitor cells?