Association of serum leptin with hypoventilation in human obesity
Association of serum leptin with hypoventilation in human obesity
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DOI：
10.1136/thorax.57.1.75
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发表时间：
2002-01-01
期刊：
影响因子：
10
通讯作者：
Grunstein, RR
中科院分区：
文献类型：
--
作者：
Phipps, PR;Starritt, E;Grunstein, RR
背景：瘦素是哺乳动物脂肪细胞产生的一种蛋白质激素。它通过一种特殊的受体在下丘脑内起作用，减少食欲，增加能量消耗。血浆瘦素水平通过中枢反馈机制与全身脂肪质量密切相关。肥胖人群的血清瘦素水平比瘦子高出四倍，这表明反馈回路失效和中枢性瘦素抵抗。在瘦素缺乏的肥胖小鼠（ob/ob小鼠）中，瘦素输注可逆转低氧剂。据推测，中枢神经系统瘦素的相对缺乏（由高循环瘦素水平表明）可能与肥胖低通气综合征（OHS）的发病机制有关。方法：测量伴有和不伴有白天高碳酸血症的肥胖和非肥胖患者的空腹早晨瘦素水平（n=56）。对每位患者进行睡眠研究、人体测量数据、肺活量测定参数和清醒时动脉血气张力测量。结果：全组血清瘦素水平与体脂率密切相关（r=0.77）。肥胖高碳酸血症患者（平均（SD） %体脂43.8(6.0)%）的空腹血清瘦素水平高于肥胖高碳酸血症患者（平均（SD） %体脂40.8(6.2)%），平均（SD）瘦素水平分别为39.1 (17.9)ng/ml和21.4 (11.4)ng/ml (p
Background: Leptin is a protein hormone produced by fat cells of mammals. It acts within the hypothalamus via a specific receptor to reduce appetite and increase energy expenditure. Plasma leptin levels correlate closely with total body fat mass operating via a central feedback mechanism. In human obesity serum leptin levels are up to four times higher than in lean subjects, indicating a failure of the feedback loop and central leptin resistance. In leptin deficient obese mice (ob/ob mice) leptin infusion reverses hypoventilotion. It was hypothesised that a relative deficiency in CNS leptin, indicated by high circulating leptin levels, may be implicated in the pathogenesis of obesity hypoventilation syndrome (OHS).Methods: Fasting morning leptin levels were measured in obese and non-obese patients with and without daytime hypercapnia (n=56). Sleep studies, anthropometric data, spirometric parameters, and awake arterial blood gas tensions were measured in each patient.Results: In the whole group serum leptin levels correlated closely with % body fat (r=0.77). Obese hypercapnic patients (mean (SD) % body fat 43.8 (6.0)%) had higher fasting serum leptin levels than eucapnic patients (mean % body fat 40.8 (6.2)%), with mean (SD) leptin levels of 39.1 (17.9) and 21.4 (11.4) ng/ml, respectively (p