OPTICAL COHERENCE TOMOGRAPHY IN RETINITIS PIGMENTOSA Reproducibility and Capacity to Detect Macular and Retinal Nerve Fiber Layer Thickness Alterations
OPTICAL COHERENCE TOMOGRAPHY IN RETINITIS PIGMENTOSA Reproducibility and Capacity to Detect Macular and Retinal Nerve Fiber Layer Thickness Alterations
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DOI：
10.1097/iae.0b013e318242b838
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发表时间：
2012-09-01
影响因子：
3.3
通讯作者：
Cuenca, Nicolas
中科院分区：
文献类型：
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作者：
Garcia-Martin, Elena;Pinilla, Isabel;Cuenca, Nicolas
目的：评价时域和傅里叶域光学相干断层扫描（OCTs）检测色素性视网膜炎（RP）黄斑和视网膜神经纤维层萎缩的能力。使用三种OCT仪器（Stratus， Cirrus和Spectralis）测试细胞内重现性。方法：80例患者80只眼（RP患者40只，健康者40只）进行视野检查，同时由同一位经验丰富的检查者使用3台OCT仪器进行3次黄斑扫描和3次视盘评估。比较健康眼和RP眼的差异。评估各OCT仪器测量结果之间的关系。通过类内相关系数和变异系数研究重复性。结果：RP患者的所有OCT参数均可见黄斑及视网膜神经纤维层萎缩。不同oct测定黄斑神经纤维层厚度与视网膜神经纤维层厚度相关，但差异有统计学意义（P < 0.05）。使用层云的重现性中等，使用卷云和谱云的重现性较好，使用谱云的trutrack技术的重现性较好。与健康眼睛相比，RP眼睛的测量结果显示出更高的变异性。结论：尽管OCT仪器之间存在高度相关，但厚度测量存在差异。傅里叶域OCT是检测RP患者视网膜神经纤维层萎缩的一种有效且可重复的技术。视网膜32:1581-1591,2012
Purpose: To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis).Methods: Eighty eyes of 80 subjects (40 RP patients and 40 healthy subjects) underwent a visual field examination, together with 3 macular scans and 3 optic disk evaluations by the same experienced examiner using 3 OCT instruments. Differences between healthy and RP eyes were compared. The relationship between measurements with each OCT instrument was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation.Results: Macular and retinal nerve fiber layer atrophies were detected in RP patients for all OCT parameters. Macular and retinal nerve fiber layer thicknesses, as determined by the different OCTs, were correlated but significantly different (P < 0.05). Reproducibility was moderately high using Stratus, good using Cirrus and Spectralis, and excellent using the Tru-track technology of Spectralis. In RP eyes, measurements showed higher variability compared with healthy eyes.Conclusion: Differences in thickness measurements existed between OCT instruments, despite there being a high degree of correlation. Fourier-domain OCT can be considered a valid and repeatability technique to detect retinal nerve fiber layer atrophy in RP patients. RETINA 32:1581-1591, 2012