Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide activated macrophages
Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide activated macrophages
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DOI：
10.1016/s0968-0896(02)00471-6
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发表时间：
2003-03-06
影响因子：
3.5
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Matsuda, H;Toguchida, I;Yoshikawa, M
雪莲根的甲醇提取物能抑制脂多糖（LPS）激活的小鼠腹腔巨噬细胞产生一氧化氮（NO）。在来自甲醇提取物的成分中，两种倍半萜内酯（木香内酯和脱氢木香内酯）和两种氨基酸-倍半萜缀合物（saussureamines A和B）有效地抑制LPS诱导的NO产生（IC 50 = 1.2-2.8 μ M）。除了木香酮和去氢木香内酯外，雪莲胺A和B不抑制iNOS酶活性，但它们抑制诱导型NO合酶的诱导和核因子-κ B的活化，与热休克蛋白72的诱导一致。(C)2002爱思唯尔科技有限公司版权所有。
The methanolic extract of the roots of Saussurea lappa CLARKE, a Chinese medicinal herb Saussureae Radix, was found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages. Among the constituents from the methanolic extract, two sesquiterpene lactones (costunolide and dehydrocostus lactone) and two amino acid-sesquiterpene conjugates (saussureamines A and B) potently inhibited LPS-induced NO production (IC50 = 1.2-2.8 muM). Saussureamines A and B in addition to costunolide and dehydrocostus lactone did not inhibit iNOS enzyme activity, but they inhibited both induction of inducible NO synthase and activation of nuclear factor-kappaB in accordance with induction of heat shock protein 72. (C) 2002 Elsevier Science Ltd. All rights reserved.