Genomics-based dissection of the cross-talk of chloroplasts with the nucleus and mitochondria in Arabidopsis
Genomics-based dissection of the cross-talk of chloroplasts with the nucleus and mitochondria in Arabidopsis
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DOI：
10.1016/j.gene.2005.03.039
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发表时间：
2005-07-18
期刊：
影响因子：
3.5
通讯作者：
Leister, D
中科院分区：
文献类型：
--
作者：
Leister, D
内生共生后叶绿体进化的特征是蓝藻基因大量转移到细胞核，随后许多编码蛋白重新路由。因此，大多数叶绿体蛋白是核编码的，这使得细胞器能够顺行(核到叶绿体)控制。叶绿体功能的调节还包括叶绿体和线粒体之间的串扰，以及逆行(叶绿体到细胞核)信号。遗传分析表明，氧化还原状态、通过叶绿素生物合成途径的通量、糖感应和活性氧物种参与了逆行信号转导。然而，信使分子(S)的身份在很大程度上仍不清楚。影响叶绿体特性的线粒体突变体的特征揭示了叶绿体-线粒体相互作用的新方面。对核叶绿体转录组的研究表明，至少存在三种不同类型的转录调控：主开关，通过诱导或抑制同一大组基因以二元模式起作用；具有大约相同数量的上调和下调基因的“混合反应”；以及支持光合作用和叶绿体基因表达的核基因特定共同调控的机制。最近发现的后一种控制模式突显了一种可能古老的协调叶绿体和核基因组表达的途径。(C)2005 Elsevier B.V.保留所有权利。
Post-endosymbiotic evolution of chloroplasts was characterized by a massive transfer of cyanobacterial genes to the nucleus, followed by re-routing of many of their encoded proteins. In consequence, most plastid proteins are nucleus-encoded, enabling an anterograde (nucleus-to-plastid) control of the organelle. The regulation of chloroplast functions includes also cross-talk between chloroplasts and mitochondria, as well as retrograde (plastid-to-nucleus) signalling. Genetic analyses reveal that redox state, flux through the chlorophyll biosynthetic pathway, sugar sensing and reactive oxygen species contribute to retrograde signalling. However, the identity of the messenger molecule(s) remains largely unknown. Novel facets of the chloroplast-mitochondrion cross-talk have been revealed by the characterization of mitochondrial mutants affected in chloroplast properties. Studies of the nuclear chloroplast transcriptome imply the existence of at least three distinct types of transcriptional regulation: a master switch, acting in a binary mode by either inducing or repressing the same large set of genes; a "mixed response" with about equal numbers of up- and down-regulated genes; and mechanisms supporting the specific co-regulation of nuclear genes for photosynthesis and for plastid gene expression. The recent discovery of the latter mode of control highlights a possibly ancient route to co-ordinate chloroplast and nuclear genome expression. (c) 2005 Elsevier B.V. All rights reserved.