SECRETORY IGA ANTIBODIES SYNERGIZE WITH IGG IN PROMOTING ADCC BY HUMAN POLYMORPHONUCLEAR CELLS, MONOCYTES, AND LYMPHOCYTES
SECRETORY IGA ANTIBODIES SYNERGIZE WITH IGG IN PROMOTING ADCC BY HUMAN POLYMORPHONUCLEAR CELLS, MONOCYTES, AND LYMPHOCYTES
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DOI：
10.1016/0008-8749(81)90435-4
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发表时间：
1981-01-01
影响因子：
4.3
通讯作者：
FANGER, MW
中科院分区：
文献类型：
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作者：
SHEN, L;FANGER, MW
分泌型IgA抗体不能单独介导多形核白细胞(PMN)、单核细胞或淋巴细胞的抗体依赖性细胞毒(ADCC)，但能显著提高这些细胞所执行的抗体依赖性细胞毒(ADCC)。这与中性粒细胞和单核细胞同时表达IgA和Ig G受体相一致，提示某些淋巴细胞可能同时携带这两种受体。提出了分泌型IgA参与免疫防御的机制。
Secretory IgA antibody which alone did not mediate antibody-dependent cytotoxicity (ADCC) by polymorphonuclear leukocytes (PMN), monocytes or lymphocytes, caused significant elevation of the IgG-ADCC carried out by these cells. This corresponds to the expression of receptors for both IgA and IgG on subpopulations of PMN and monocytes, and implies that some lymphocytes may bear both receptors. A mechanism whereby secretory IgA participates in immune defense is suggested.