The association between urinary sodium to potassium ratio and bone density in middle-aged Chinese adults
The association between urinary sodium to potassium ratio and bone density in middle-aged Chinese adults
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DOI：
10.1007/s00198-016-3835-9
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发表时间：
2017-03-01
影响因子：
4
通讯作者：
Chen, Y. M.
中科院分区：
文献类型：
--
作者：
Cao, W. T.;He, J.;Chen, Y. M.
钠和钾对骨骼健康的联合影响仍不确定。我们检查了钠、钾的尿排泄及其比率与骨矿物质密度 (BMD) 之间的关联，并报告了女性尿钠钾比与 BMD 之间存在负相关，但男性则不然。多项研究表明，较高的钠或较低的钾摄入量与骨骼健康状况不佳有关。然而，很少有研究检验它们的联合效应。我们研究了中国成年人尿液中钠、钾的排泄量以及钠钾比与 BMD 的关系。这项基于社区的横断面研究包括中国广州的 2202 名女性和 1063 名男性（40-75 岁）。采用双能X射线骨密度仪测量全身、腰椎、髋部部位的BMD。测量早晨空腹首次排尿样本中钠、钾和肌酐的浓度，然后将肌酐调整后的值用于进一步分析。一般信息通过面对面访谈收集。对于女性，经过多变量调整后，尿钠钾比与全身、全髋、转子和转子间的BMD呈负相关（所有p趋势<0.05）。这些地点极端四分位数之间的平均 BMD 差异范围为 1.50% 至 2.98%（所有 p < 0.05）。尿钠/肌酐也观察到类似但不太显着的关联，唯一显着差异出现在转子处 (2.00 %，p = 0.016)。我们没有发现女性 BMD 与尿钾以及男性尿钠/肌酐、钾/肌酐或其比值有任何显着相关性。我们的研究结果表明，尿钠与钾的比值（而非个体肌酐调整后的钠或钾值）是女性 BMD 的良好预测因子，但对于男性则不然。
The joint effect of sodium and potassium on bone health remains uncertain. We examined the associations between urinary excretion of sodium, potassium, and their ratio and bone mineral density (BMD), and reported an inverse association between urinary sodium-to-potassium ratio and BMD in women, but not in men.Several studies have suggested that a higher sodium or lower potassium intake is associated with poor bone health. However, few studies have examined their joint effects. We examined the associations of urinary excretion of sodium, potassium, and the sodium-to-potassium ratio with BMD in Chinese adults.This community-based, cross-sectional study included 2202 women and 1063 men (40-75 years) in Guangzhou, China. The BMD of the whole body, lumbar spine, and hip sites were measured by dual-energy x-ray absorptiometry. The concentrations of sodium, potassium, and creatinine of the fasting morning first-void urine sample were measured, and creatinine-adjusted values were then used for further analyses. General information was collected via face-to-face interviews.For women, after multivariable adjustment, the urinary sodium-to-potassium ratio was inversely associated with BMD at the whole body, total hip, trochanter, and intertrochanter (all p trend < 0.05). The mean BMD differences between extreme quartiles ranged from 1.50 to 2.98 % at these sites (all p < 0.05). Similar, but less significant, associations were observed for urinary sodium/creatinine, for which the only significant difference was found at the trochanter (2.00 %, p = 0.016). We did not find any significant associations of BMD with urinary potassium in women and with urinary sodium/creatinine, potassium/creatinine, or their ratio in men.Our findings suggest that the urinary sodium-to-potassium ratio, but not individual creatinine-adjusted values of sodium or potassium, is a good predictor of BMD in women, but not in men.