Adult psychiatric status of hyperactive boys grown up
Adult psychiatric status of hyperactive boys grown up
复制标题
DOI：
10.1176/ajp.155.4.493
复制
发表时间：
1998-04-01
影响因子：
17.7
通讯作者：
LaPadula, M
中科院分区：
文献类型：
--
作者：
Mannuzza, S;Klein, RG;LaPadula, M
目的：许多研究已经检查了注意缺陷多动障碍（ADHD）儿童的青少年和年轻成人的命运。与此形成鲜明对比的是，人们对这些儿童的成人结局知之甚少。只有两项关于成年后精神状态的对照前瞻性研究。本研究旨在进一步了解这种常见儿童疾病的自然过程。方法：这是一项前瞻性的随访研究，对象是临床诊断的、智力平均的白色男孩，他们在平均年龄为7.3岁时被教师转诊到儿童精神病研究诊所。在平均年龄为24.1岁时，85名先证者（82%的儿童队列）和73名对照受试者（94%的青少年对照受试者）直接接受了训练有素的临床医生的采访，这些临床医生对群体状况一无所知。结果如下：对先证者和对照受试者的评估表明，先证者中反社会人格障碍（12%对3%）和非酒精性物质滥用（12%对4%）的患病率显着较高，而情绪障碍（4%对4%）和焦虑症（2%对7%）没有显着差异。在成人随访中，ADHD是罕见的，仅发生在4%的先证者中（没有比较对象）。结论：本研究的结果与作者先前报道的主要发现一致。他们强烈建议，ADHD儿童有显着更高的风险，以反社会和物质相关障碍为标志的特定负面过程。
Objective: Numerous studies have examined the adolescent and young adult fate of children with attention deficit hyperactivity disorder (ADHD). In marked contrast, relatively little is known about the adult outcome of these children. There have been only two controlled, prospective studies of psychiatric status into adulthood. The present study was conducted to gain further understanding of the natural course of this common childhood condition. Method: This was a prospective follow-up of clinically diagnosed, white boys of average intelligence who were referred by teachers to a child psychiatric research clinic at an average age of 7.3 years. At a mean age of 24.1 years, 85 probands (82% of the childhood cohort) and 73 comparison subjects (94% of adolescent comparison subjects) were directly interviewed by trained clinicians who were blind to group status. Results: Evaluations of the probands and comparison subjects indicated significantly higher prevalences of antisocial personality disorder (12% versus 3%) and nonalcohol substance abuse (12% versus 4%) in the probands, whereas mood disorders (4% versus 4%) and anxiety disorders (2% versus 7%) were not significantly different. At adult follow-up, ADHD was rare, occurring in only 4% of the probands (no comparison subjects). Conclusions: The results of the present study are consistent with the authors' previously reported major findings. They strongly suggest that children with ADHD are at significantly higher risk for a specific negative course marked by antisocial and substance-related disorders.