Magnetite nanoparticles with high heating efficiencies for application in the hyperthermia of cancer
Magnetite nanoparticles with high heating efficiencies for application in the hyperthermia of cancer
复制标题
DOI：
10.1016/j.msec.2010.04.016
复制
发表时间：
2010-08-30
影响因子：
7.9
通讯作者：
Doi, Masaaki
中科院分区：
文献类型：
--
作者：
Li, Zhixia;Kawashita, Masakazu;Doi, Masaaki
磁热疗是一种安全的肿瘤治疗方法。间隙型交流磁场（100 kHz，100-300 Oe）有望在临床上应用于磁热疗。在这项研究中，磁铁矿纳米粒子（MNP）的尺寸从8到413 nm的变化，使用化学共沉淀和氧化沉淀法合成，以找到最佳的粒径，显示出高的加热效率，在施加的磁场。在施加的磁场中，测量MNP浓度为58 mg Fe/ml的琼脂体模中颗粒的体外加热效率。在120 Oe的磁场中，对于尺寸为8 nm的MNP，琼脂体模在30 s内的温度升高（AT）为9.3 ℃，但对于其他样品则较小，而在300 Oe的磁场中，对于尺寸为24 nm的MNP，Δ T = 55 ℃，对于尺寸为8 nm的MNP，Δ T = 25 ℃。在300 Oe的磁场中具有24 nm尺寸的MNP的优异的加热效率可能是由于磁性颗粒的弛豫和磁滞损耗两者的效果的组合。据信，具有8-24 nm尺寸的MNP将可用于癌症的原位热疗治疗。(C)2010 Elsevier B. V.保留所有权利。
Magnetic hyperthermia is a safe method for cancer therapy. A gap-type alternating current magnetic field (100 kHz, 100-300 Oe) is expected to be clinically applicable for magnetic hyperthermia. In this study, magnetite nanoparticles (MNPs) varying in size from 8 to 413 nm were synthesized using a chemical coprecipitation and an oxidation precipitation method to find the optimum particle size that shows a high heating efficiency in an applied magnetic field. The particles' in vitro heating efficiency in an agar phantom at an MNP concentration of 58 mg Fe/ml was measured in an applied magnetic field. In a magnetic field of 120 Oe, the temperature increase (AT) of the agar phantom within 30 s was 9.3 degrees C for MNPs with a size of 8 nm, but was less for the other samples, while in a magnetic field of 300 Oe, Delta T = 55 degrees C for MNPs with a size of 24 nm, and Delta T = 25 degrees C for MNPs with a size of 8 nm. The excellent heating efficiency of MNPs with a size of 24 nm in a magnetic field of 300 Oe may be due to a combination of the effects of both relaxation and hysteresis losses of the magnetic particles. It is believed that MNPs with a size of 8-24 nm will be useful for the in situ hyperthermia treatment of cancer. (C) 2010 Elsevier B.V. All rights reserved.