Remaking memories: Reconsolidation updates positively motivated spatial memory in rats
Remaking memories: Reconsolidation updates positively motivated spatial memory in rats
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DOI：
10.1101/lm.023408.111
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发表时间：
2012-03-01
影响因子：
2
通讯作者：
Fellous, Jean-Marc
中科院分区：
文献类型：
--
作者：
Jones, Bethany;Bukoski, Elizabeth;Fellous, Jean-Marc
有强有力的证据表明，记忆的重新激活会将其恢复到不稳定状态，启动称为重新巩固的重新稳定过程，从而允许更新记忆。在这项研究中，我们使用啮齿类动物中的一种新的积极激励的空间任务来研究依赖于重新激活的更新，该任务是专门为模拟人类列表学习范式而设计的。第一天，训练老鼠跑向三个喂食器（列表 1）以获得奖励。第 2 天，训练大鼠在与第 1 天相同（提醒条件）或不同（无提醒条件）的实验环境中跑向 3 个不同的喂食器（列表 2）。第 3 天，提示大鼠回忆列表 1。在列表 1 回忆过程中，处于提醒条件下的大鼠比无提醒条件下的大鼠访问列表 2 喂食器（入侵）的次数明显更多，这表明提醒触发了重新激活并允许整合列表 2 项目进入 列表 1。这种提醒效果对于重新激活的列表 1 记忆是有选择性的，因为在第 3 天回忆列表 2 时没有发生侵入。当检索发生在与编码时使用的上下文不同的上下文中时，没有发生侵入，表明更新的记忆的表达取决于检索上下文。最后，在学习列表 2 后立即检索时，侵入程度最高，而在 1-4 小时后检索时，侵入程度普遍下降，这表明列表 2 记忆与列表 1 的短期检索竞争。这些结果证明了记忆随时间的动态性质以及环境背景在记忆处理的不同阶段的影响。
There is strong evidence that reactivation of a memory returns it to a labile state, initiating a restabilization process termed reconsolidation, which allows for updating of the memory. In this study we investigated reactivation-dependent updating using a new positively motivated spatial task in rodents that was designed specifically to model a human list-learning paradigm. On Day 1, rats were trained to run to three feeders (List 1) for rewards. On Day 2, rats were trained to run to three different feeders (List 2) in either the same (Reminder condition) or a different (No Reminder condition) experimental context than on Day 1. On Day 3, rats were cued to recall List 1. Rats in the Reminder condition made significantly more visits to List 2 feeders (intrusions) during List 1 recall than rats in the No Reminder condition, indicating that the reminder triggered reactivation and allowed integration of List 2 items into List 1. This reminder effect was selective for the reactivated List 1 memory, as no intrusions occurred when List 2 was recalled on Day 3. No intrusions occurred when retrieval took place in a different context from the one used at encoding, indicating that the expression of the updated memory is dependent upon the retrieval context. Finally, the level of intrusions was highest when retrieval took place immediately after List 2 learning, and generally declined when retrieval occurred 1-4 h later, indicating that the List 2 memory competed with short-term retrieval of List 1. These results demonstrate the dynamic nature of memory over time and the impact of environmental context at different stages of memory processing.