Fast determination of lipophilicity by HPLC
Fast determination of lipophilicity by HPLC
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DOI：
10.1365/s10337-005-0608-6
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发表时间：
2005-09-01
期刊：
影响因子：
1.7
通讯作者：
Carrupt, PA
中科院分区：
文献类型：
--
作者：
Ayouni, L;Cazorla, G;Carrupt, PA
通过对代表不同官能团的29个分子的研究，提出了一种快速测定亲脂性的反相高效液相色谱方法。使用短柱填充极性包埋相和辛醇饱和水作为直接测量log k(w)的洗脱剂。对于辛醇/水体系中logp小于3.2的溶质，可以避免外推log k(w)测量值。与直接测量相比，生产率的提高和分析的简单性表明了这种方法对工业应用的有用性。在文献中发现的log P值与测量的log k(w)值之间获得了良好的相关性。
A rapid method for the determination of lipophilicity by reversed-phase high-performance liquid chromatography is presented with a study of a set of 29 molecules representing various functional groups. The use of a short column packed with a polar-embedded phase and octanol-saturated water as eluent for direct measurement of log k(w) is described. Extrapolation for log k(w) measurements can be avoided for solutes having log P in the octanol/water system of less than 3.2. The gain in terms of productivity and simplicity of analysis over the direct measurement shows the usefulness of this method for industrial applications. Good correlations between log P values found in the literature and measured log k(w) values were obtained.