Weight faltering in infancy and IQ levels at 8 years in the Avon Longitudinal Study of Parents and Children
Weight faltering in infancy and IQ levels at 8 years in the Avon Longitudinal Study of Parents and Children
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DOI：
10.1542/peds.2006-2295
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发表时间：
2007-10-01
期刊：
影响因子：
8
通讯作者：
Drewett, Robert F.
中科院分区：
文献类型：
--
作者：
Emond, Alan M.;Blair, Peter S.;Drewett, Robert F.
目标。我们的目标是调查发育不良（定义为出生后9个月体重不稳）与8年后智商水平之间的关系。体重增加（以初始体重为条件）从出生到8周，8周到9个月，以及出生到9个月是对来自雅芳父母和儿童纵向研究的足月婴儿进行测量的。体重蹒跚被定义为那些有条件的体重增加低于第5百分位的婴儿，他们被作为对照组与其他队列进行比较。在8岁时，使用韦氏儿童智力量表第三版对5771名无重大先天性异常的足月出生婴儿进行了智商测试。平均（SD）智商得分为104.7(16.3)（总），107.6(16.5)（言语）和100.2(16.9)（表现）。从出生到9个月体重不稳定的孩子在8岁时的总智商平均下降了- 2.71分，相当于0.17标准差。从出生到8周的体重增加与儿童8岁时的智商呈正相关。尽管控制了婴儿生长和儿童智商的相关性，但这在多变量回归中仍然是显著的；体重增加1个标准差与总智商得分0.84分的差异有关。与早期体重下降相比，8周到9个月的体重增加与8岁时的智商无关。婴儿时期发育不良与8岁时持续的智商缺陷有关；出生至8周为生长迟缓的关键期。婴儿从出生到8周的生长与后来的智力发展之间的关系在整个体重速度范围内近似为线性。
OBJECTIVE. Our goal was to investigate the association between failure to thrive ( defined as weight faltering in the first 9 months of life) and IQ levels 8 years later.METHODS. Weight gain ( conditional on initial weight) from birth to 8 weeks, 8 weeks to 9 months, and birth to 9 months was measured on term infants from the Avon Longitudinal Study of Parents and Children. Cases of weight faltering were defined as those infants with a conditional weight gain below the 5th centile who were compared with the rest of the cohort as the control group. At the age of 8 years, 5771 infants born at term with no major congenital abnormalities had IQ measured by using the Wechsler Intelligence Scale for Children, Third Revision.RESULTS. Mean (SD) IQ scores were 104.7 (16.3) ( total), 107.6 (16.5) ( verbal), and 100.2 (16.9) ( performance). Children whose weight faltered from birth to 9 months had a total IQ that was significantly lower by an average of - 2.71 points at 8 years, equivalent to 0.17 SD. Weight gain from birth to 8 weeks had a positive linear association with child IQ at 8 years. This remained significant in a multivariate regression despite controlling for correlates of both infant growth and child IQ; 1 SD of weight gain was associated with a difference of 0.84 points in the total IQ score. In contrast to early weight faltering, weight gain from 8 weeks to 9 months was not related to IQ at 8 years.CONCLUSIONS. Failure to thrive in infancy was associated with persisting deficits in IQ at 8 years; the critical period for growth faltering was birth to 8 weeks. The relationship between infant growth from birth to 8 weeks and later intellectual development was approximately linear over the whole range of weight velocities.