Long Non-Coding RNAs Involved in Immune Responses.
Long Non-Coding RNAs Involved in Immune Responses.
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DOI：
10.3389/fimmu.2014.00573
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发表时间：
2014
影响因子：
7.3
通讯作者：
Akimitsu N
中科院分区：
文献类型：
--
作者：
Imamura K;Akimitsu N
大量不编码蛋白质的人类RNA转录物被定义为非编码RNA（ncRNA）。这些ncRNA分为两类不同长度的ncRNA：短ncRNA和长ncRNA。MicroRNA是一类主要的短ncRNA，长度约为22个核苷酸，在转录后水平调节基因表达。长链非编码RNA（lncRNA）的长度超过200个核苷酸，在多种生物学途径中发挥作用。本文就lncRNA在免疫应答中的作用进行综述。
A large number of human RNA transcripts, which do not encode proteins are defined as non-coding RNAs (ncRNAs). These ncRNAs are divided into two classes of different lengths; short and long ncRNAs. MicroRNAs are a major class of short ncRNAs, ~22 nucleotides in length that regulate gene expression at the post-transcriptional level. Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and play roles in various biological pathways. In this review, we summarize the functions of lncRNAs which regulate immune responses.