Effects of prolonged fasting on fatigue and quality of life in patients with multiple sclerosis
Effects of prolonged fasting on fatigue and quality of life in patients with multiple sclerosis
复制标题
DOI：
10.1007/s10072-016-2518-9
复制
发表时间：
2016-06-01
影响因子：
3.3
通讯作者：
Nasr, Zahra
中科院分区：
文献类型：
--
作者：
Etemadifar, Masoud;Sayahi, Farnaz;Nasr, Zahra
斋戒是世界上几个伟大宗教推荐的崇拜之一。在斋月期间，昼夜节律和饮食模式的变化导致身体的生理，生化和激素变化。许多有健康问题的穆斯林会询问他们的医生斋月期间禁食的可行性和安全性。在这项研究中，我们的目的是评估斋月禁食对多发性硬化症（MS）患者生活质量和疲劳的影响。本研究纳入了根据McDonald标准的轻度残疾（EDSS评分为千分之一货币符号3）的复发缓解型MS（RRMS）患者。分别使用经验证的波斯版改良疲劳影响量表（MFIS）和多发性硬化症生活质量-54（MSQOL-54）问卷评估疲劳和生活质量。218例患者（150例女性和68例男性）入组本研究。空腹前后MSIF的平均总分之间没有统计学显著差异（25.50 +/- 13.81 vs 26.94 +/- 16.65; p = 0.58）。禁食后，生活质量的平均身体健康和心理健康复合指标显著增加（分别为p = 0.008和p = 0.003）。尽管观察到缺乏对疲劳的有利影响，但我们的结果显示，一旦斋月结束，MS患者的生活质量就会提高。这是否与斋月相关的禁食特别相关，值得在适当设计的大型前瞻性临床研究中进一步测试。
Fasting is one of the recommended worships of several great religions in the world. During the month of Ramadan, circadian rhythm and pattern of eating changes result in physiological, biochemical and hormonal changes in the body. Many Muslims with medical conditions ask their physicians about the feasibility and safety of fasting during Ramadan. In this study, we aim to assess the effect of Ramadan fasting on the quality of life and fatigue in multiple sclerosis (MS) patients. Relapsing-remitting MS (RRMS) patients according to McDonald's criteria who had mild disability (EDSS score a parts per thousand currency sign3) were included in this study. Fatigue and quality of life were were assessed using the validated Persian versions of modified fatigue impact scale (MFIS) and multiple sclerosis quality of life-54 (MSQOL-54) questionnaires, respectively. 218 patients (150 females and 68 males) were enrolled in our study. There was no statistically significant difference between the mean total score of MSIF before and after fasting (25.50 +/- 13.81 versus 26.94 +/- 16.65; p = 0.58). The mean physical health and mental health composites of quality of life increased significantly after fasting (p = 0.008 and p = 0.003 respectively). Despite the observed lack of favorable effects on fatigue, our results showed increased quality of life of MS patients once Ramadan has ended. Whether this is specifically related to Ramadan-related fasting deserves further testing in appropriately designed larger prospective clinical studies.