Development and specificity of inhibitory terminal arborizations in the central nervous system.
Development and specificity of inhibitory terminal arborizations in the central nervous system.
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中枢神经系统抑制性末端树枝化的发育和特异性。
DOI：
10.1002/neu.480220805
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Siverls,V
中科院分区：
文献类型：
--
作者：
Sanes,DH;Siverls,V
本研究考察了沙鼠中枢听觉脑干单一抑制性分枝的形态学发展。利用脑片制备方法，用辣根过氧化物酶（HRP）填充梯形体（MNTB）内侧核的神经元，沿外侧上橄榄（LSO）的张力异位轴分析其完整的树形。新生动物的突起显示了在LSO内有序排列的明确的乔木。从轴突通路可以明显看出，MNTB传入在到达突触后群体后可以纠正投射错误。随着发展的进展，一些机构在统计司内建立了分散或不适当的预测。这些未成熟的分枝在出生后18-25天不再明显。在12-13天和18-25天，通过测量终端扣在频率轴上分布的距离来量化乔木的解剖特异性。老年动物的这一距离明显缩短。此外，在12-13天和18-25天期间，每乔木的平均花数显著减少。在15-16天内，最大核横截面积继续增加，表明精细树杈在突触后结构中所占的比例更小。综上所述，这些观察结果表明，中枢抑制性乔木形成了旺盛的接触，必须在发育过程中消除。
This study examined the morphological development of single inhibitory arborizations in the gerbil central auditory brain stem. Using a brain slice preparation, neurons of the medial nucleus of the trapezoid body (MNTB) were filled with horseradish peroxidase (HRP), and their complete arborizations were analyzed along the tonotopic axis of the lateral superior olive (LSO). The projections in neonatal animals displayed well‐defined arbors that were ordered appropriately within the LSO. It was evident from the axonal pathways that the MNTB afferents could correct for projection errors after reaching the postsynaptic population. As development progressed, a number of arbors established diffuse or inappropriate projections within the LSO. These immature arborizations were no longer apparent by 18–25 days postnatal. The anatomical specificity of arbors at 12–13 and 18–25 days was quantified by measuring the distance that terminal boutons spread across the frequency axis. There was a significant reduction of this distance in older animals. In addition, there was a significant reduction in the mean number of boutons per arbor between 12–13 days and 18–25 days. The maximum nucleus cross‐sectional area continued to increase through 15–16 days, indicating that the refined arbors occupied an even smaller fraction of the postsynaptic structure. Taken together, these observations suggest that central inhibitory arbors form exuberant contacts that must be eliminated during development.
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神经递质受体的免疫细胞化学。
DOI：
10.1002/jemt.1060150108
发表时间：
1990
期刊：
Journal of electron microscopy technique
影响因子：
--
作者：
R. J. Wenthold;R. Altschuler;D. Hampson
通讯作者：
D. Hampson
影响因子：
56.9
作者：
SHATZ, CJ;STRYKER, MP
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DOI：
--
发表时间：
1985
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
K. Glendenning;K. A. Hutson;R. Nudo;R. Masterton
通讯作者：
R. Masterton
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影响因子：
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作者：
Woolf,NK;Ryan,AF
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Ryan,AF
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DOI：
10.1523/jneurosci.05-12-03228.1985
发表时间：
1985
期刊：
Journal of electron microscopy technique
影响因子：
--
作者：
D. Sakaguchi;R. Murphey
通讯作者：
R. Murphey