Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors
Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors
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DOI：
10.1021/jm500823a
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发表时间：
2014-11-13
影响因子：
7.3
通讯作者：
Rotella, David P.
中科院分区：
文献类型：
--
作者：
Bhat, Rohit;Tummalapalli, Sreedhar R.;Rotella, David P.
热休克蛋白90（Hsp90）抑制剂的发现和临床开发不断取得进展。许多Hsp90抑制剂正在进行临床试验，与蛋白质不同区域结合的新化学型以及同种型选择性化合物的临床前发现是活跃的研究领域。本次审查将重点介绍自2010年以来在该领域取得的进展。
The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.