Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training
Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training
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DOI：
10.1152/jappl.1996.81.5.2095
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发表时间：
1996-11-01
影响因子：
3.3
通讯作者：
Abumrad, N
中科院分区：
文献类型：
--
作者：
Nissen, S;Sharp, R;Abumrad, N
在两个实验中研究了在饮食中补充亮氨酸代谢物β-羟基-β-甲基丁酸酯（HMB）的效果。在研究1中，受试者（n = 41）被随机分为三个水平的HMB补充（0、1.5或3.0g HMB/天）和两个蛋白质水平（正常，117 g/天，或高，175 g/天），并且举重1.5h，3天/周，持续3周。在研究2中，受试者（n = 28）喂食0或3.0 g HMB/天，并举重2-3 h，6天/周，持续7周。在研究1中，HMB显著降低运动诱导的肌肉蛋白水解的升高，如在运动的前2周期间通过尿S-甲基组氨酸测量的（线性降低，P < 0.04）。血浆肌酸磷酸激酶也随着HMB补充而降低（第3周，线性降低，P < 0.05）。在研究的每一周期间，与未补充的受试者相比，通过HMB补充增加了体重增加（线性增加，P < 0.02）。在研究2中，在研究的第2和4-6周，补充HMB的受试者的去脂质量与未补充组相比显著增加（P < 0.05）。总之，补充1.5或3 g HMB/天可以部分预防运动诱导的蛋白水解和/或肌肉损伤，并导致与阻力训练相关的肌肉功能获得更大收益。
The effects of dietary supplementation with the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) were studied in two experiments. In study 1, subjects (n = 41) were randomized among three levels of HMB supplementation (0, 1.5 or 3.0 g HMB/day) and two protein levels (normal, 117 g/day, or high, 175 g/day) and weight lifted for 1.5 h 3 days/wk for 3 wk. In study 2, subjects (n = 28) were fed either 0 or 3.0 g HMB/day and weight lifted for 2-3 h 6 days/wk for 7 wk. In study 1, HMB significantly decreased the exercise-induced rise in muscle proteolysis as measured by urine S-methylhistidine during the first 2 wk of exercise (linear decrease, P < 0.04). Plasma creatine phosphokinase was also decreased with HMB supplementation (week 3, linear decrease, P < 0.05). Weight lifted was increased by HMB supplementation when compared with the unsupplemented subjects during each week of the study (linear increase, P < 0.02). In study 2, fat-free mass was significantly increased in HMB-supplemented subjects compared with the unsupplemented group at 2 and 4-6 wk of the study (P < 0.05). In conclusion, supplementation with either 1.5 or 3 g HMB/day can partly prevent exercise-induced proteolysis and/or muscle damage and result in larger gains in muscle function associated with resistance training.